The behavior of inclusions in castings was studied using radioactive labeling of oxide particles located by Positron Emission Particle Tracking (PEPT). This uses the isotope 18F, which has a half-life of 110 minutes, and allows particle detection within an accuracy of a few mm. Alumina and glass particles with a size range of 110 to 600 μm were made radioactive by an ion-exchange/surface adsorption process involving irradiated water. Individual radioactive particles were placed in resin-bonded sand moulds at known initial positions, and the moulds were filled with Al alloy, causing the particle to be entrained into the metal stream during the casting process. A modular γ-ray positron camera was used to track the paths of the particles within the mould, demonstrating the applicability of the technique to the study of inclusion behaviour in castings.