In this work a comparative study between microstructure and mechanical properties of aluminum-nickel alloys with different contents of nickel was carried out. Alloys were produced by powders metallurgy. Characterization results indicates that the microstructure of the aluminum-nickel alloys present a thin and homogeneous distribution of an intermetallic compound in the aluminum’s matrix, identified as Al3Ni. Furthermore, it was find out that the amount of intermetallic Al3Ni increase as the nickel content in the alloy rises. Regarding the mechanical properties evaluated; it was establishes that the hardness, compression and flexion resistances also were improved due to the presence of the intermetallic compound.