Paper Title:
Preparation and Characterization of Coenzyme Q10-Loaded Nanostructured Lipid Carriers
  Abstract

The enhancement of stability of light sensitive CoQ10 was achieved by preparation of coenzyme Q10-loaded Nanostructured Lipid Carriers through High Pressure Homogenization (HPH). Well-dissolved lipids of CoQ10 were selected, optimized ratio of emusifiers and lipids were determined for the formulation. Obtained by photon correlation spectroscopy (PCS), the mean particle size of CoQ10-NLC was 112 ± 7 nm within 60 days after preparation. In terms of centrifugal stability, results of laser diffraction (LD) analysis eliminated the existence of aggregated particles with micrometers and showed almost no size growth before and after centrifugation. Zeta potential values were from -50 to -55 mV with pH in the range of 6.56–6.72. The concentration of CoQ10-NLC measured by UV-Vis spectroscopy was as high as 8.13 mg/mL.

  Info
Periodical
Chapter
Chapter 1: Frontiers of Nanoscience and Technology
Edited by
Ran Chen
Pages
170-174
DOI
10.4028/www.scientific.net/MSF.694.170
Citation
Q. Xia, J. Y. Wu, "Preparation and Characterization of Coenzyme Q10-Loaded Nanostructured Lipid Carriers", Materials Science Forum, Vol. 694, pp. 170-174, 2011
Online since
July 2011
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$32.00
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