Paper Title:
Study on Cytotoxicity of Nanoscale Zero Valent Iron Particles
  Abstract

Although small nZNI nanoparticles are useful in various applications, the biosafety of this material needs to be evaluated. In this study, Escherichia coli cells were exposed to 0, 112, 560, 1120 mg/L of nano-Fe0particles, respectively. Experiments were carried out to examine the activities of lactate dehydrogenase (LDH), cellular superoxide dismutase (SOD), and malondialdehyde (MDA) after exposure to nano-Fe0 for 24h. The activities of LDH and the levels of MDA were significantly increased (P<0.05), respectively. However, the activities of SOD were significantly decreased (P<0.05). A dose dependent increase in lipid peroxidation product (MDA) contents was observed in treatment groups(r=0.945, P<0.05).The result demonstrated that the damage to cell membranes and oxidative stress were mechanisms of nano-Fe0 ecotoxicity.

  Info
Periodical
Chapter
Chapter 1: Frontiers of Nanoscience and Technology
Edited by
Ran Chen
Pages
224-228
DOI
10.4028/www.scientific.net/MSF.694.224
Citation
X. Wang, M. Y. Dong, L. Liu, Y. Liu, Z. H. Jin, T. L. Li, "Study on Cytotoxicity of Nanoscale Zero Valent Iron Particles", Materials Science Forum, Vol. 694, pp. 224-228, 2011
Online since
July 2011
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Price
$32.00
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