Paper Title:
Atomic Force Microscopy-Based Investigation on the Elastic Properties of Oligodendrocytes
  Abstract

As the leading killer of human health in the current age, cancer is concerned widely in the medical profession. As the popularizations of atomic force microscopy (AFM) in micro-biology, measuring the mechanical properties of cells by AFM is gradually applied in the diagnosis and treatment of cancer. In this paper, the scanning parameters were optimized and the indentation experiments in different parts of oligodendrocytes were carried out to test the elastic modulus of oligodendrocytes. In order to evaluate the elastic modulus accurately, nine areas on each cell were selected, and for each area, a small matrix of indentation point was made. The results indicated that elastic modulus of the center part of cancer cell is softer than that in the edge, and the one of the normal cell are 3 order of magnitude harder than the cancer cell.

  Info
Periodical
Chapter
Chapter 2: Frontiers of Materials Science and Engineering
Edited by
Ran Chen
Pages
886-890
DOI
10.4028/www.scientific.net/MSF.694.886
Citation
J. H. Wang, M. Yu, L. Liu, J. Zhao, Y. C. Liang, S. Dong, "Atomic Force Microscopy-Based Investigation on the Elastic Properties of Oligodendrocytes", Materials Science Forum, Vol. 694, pp. 886-890, 2011
Online since
July 2011
Export
Price
$32.00
Share

In order to see related information, you need to Login.

In order to see related information, you need to Login.

Authors: Jing He Wang, Miao Yu, Li Liu, Jie Zhao, Hong Xiang Wang
Chapter 2: Frontiers of Materials Science and Engineering
Abstract:In order to reveal variation of mechanical properties of hepatoma cells with nanometer resolution, atomic force microscopy (AFM)-based...
869
Authors: Jia Jia Tu, Guo Wei Liang
Chapter 1: Mechanical Engineering
Abstract:A solar cells test system that can be used in the natural environment is designed, which can complete a variety of test experiments on...
26
Authors: Chyung Ay, Cheng Chang Lien, Chung Yu Yeh
Chapter 7: Dynamics of Mechanisms and Systems
Abstract:This study developed an automatic monitoring system with a vertical mechanical force to stimulate cancerous cartilage sw1353 cells. The...
2131
Authors: Ju Nan Kuo, Tian Lin Rao
Chapter 2: Advanced Bio and Medical Engineering, Applications of Bioinformatics and Genetic Engineering
Abstract:Cell-cell interactions through direct contact play a critical role in cellular communication and coordination. In this paper, the adhesion...
278
Authors: Yuan Chen Wei, Bao Dong Bai
Chapter 2: Advanced Bio and Medical Engineering, Applications of Bioinformatics and Genetic Engineering
Abstract:This paper provides an economical and high efficient kind of microfluidic chip device which can investigate cells' response under different...
357