Paper Title:
A Novel Antimicrobial Nano-Composite Porous Material for Bone Repair
  Abstract

In this paper, isoniazid (INH)-loaded poly (ε-caprolactone) microspheres with a special microporous surface and relatively high drug loading were fabricated by an oil-in-oil (O/O) solvent evaporation method. Meanwhile the microspheres were produced by an oil-in-water (O/W) method for comparison. The technological parameters such as the concentration of surfactant, the volume of continuous phase and the quantity of the drug were investigated systematically. The microspheres morphology, their size distribution and the viscosity of both the dispersed and continuous phase were characterized. The results indicate that the O/O solvent evaporation method is a feasible approach to encapsulate micromolecular and hydrophilic drugs in PCL. This opens the door for INH-loaded microspheres able to release drugs and thereby improve the therapy of tuberculosis of bones and joints in the future.

  Info
Periodical
Edited by
Hyungsun Kim, Jian Feng Yang, Chuleol Hee Han, Somchai Thongtem and Soo Wohn Lee
Pages
517-520
DOI
10.4028/www.scientific.net/MSF.695.517
Citation
P. P. Luo, J. D. Li, Y. Zuo, X. Wu, Y. B. Li, "A Novel Antimicrobial Nano-Composite Porous Material for Bone Repair", Materials Science Forum, Vol. 695, pp. 517-520, 2011
Online since
July 2011
Export
Price
$32.00
Share

In order to see related information, you need to Login.

In order to see related information, you need to Login.

Authors: Alina Prună, V. Brânzoi, F. Brânzoi
Abstract:The influence of electrolyte additions on the corrosion of zinc in aqueous solutions of KOH has been determined using electrochemical and...
233
Authors: Zi Chong Zhuang, Bao Hua Huang, Jun Liu, Yu Jing Lu, Zhan Chang Pan, Kun Zhang
Chapter 4: Catalyst, Inhibitors and Reaction
Abstract:A new ionic liquid, N-octyl-2-pyrrolidonium chloride (NOPC), were synthesized and evaluated as inhibitors for mild steel (Q235) corrosion in...
651
Authors: Mubarak Abdullah Saleh, Salam A. Mohammed, Ezzat C Abdullah, Laith A. Hashim
Chapter 5: Developments in Biocomposites, Bioethanol and Green Materials
Abstract:The use of reduction and nucleation technologies in nanosize active pharmaceutical ingredient (API) is as an enabling to bring improved drug...
234
Authors: Li Zheng, Ji Liu, Zhi Hua Tao, Wei He, Ding Jun Xiao, Ze Tan
Chapter 1: Materials and Processing Technology
Abstract:This paper is mainly to discuss that myclobutanil as corrosion inhibitor and its corrosion efficiency were evaluated via electrochemical...
229