A new ZrO2 nano-composite ceramic tool and die material was prepared with vacuum hot pressing technology. The friction and wear behaviors of ZrO2 nano-composite ceramic tool and die materials in sliding against 45 chilled steel rings under dry friction were investigated by using an MMW-1A abrasion wear tester. The mechanical properties and the friction and wear properties of the composites with various compositions and contents were studied. It is indicated that the changing trends of the wear rate and the mechanical properties of the composites with the change of TiB2 and Al2O3 contents are roughly the same, but the friction coefficient is not obviously. The friction and wear properties and the mechanical properties are finer when the TiB2 and Al2O3 content is both 10%.