Ceramic bricks are one of the most widely used materials in both commercial and residential buildings. Ceramic bricks play a relevant role in the Brazilian economy. The basic input material for this industry is red clay. As environmental problems increase, the need for environment-friendly building design increases. To achieve this, architects and engineers need reliable data on the environmental impacts of various building materials, including ceramic bricks. In this paper a comparative Life Cycle Assessment between two ceramic brick production units in Santa Catarina State, Brazil, has been carried in a comparative approach. Key impact categories, including fossil fuel use, global warming, ozone depletion, ecotoxicity, and human toxicity were assessed. The analysis has shown a particular relevance of the respiratory effects in both systems and the critical point has been found in the fuel used in the furnace for firing the bricks which are responsible, during the ring process, for the relevant CO2 emissions.