New compositions of dental adhesives with nanoparticles of metals were developed, in order to achieve prolonged bactericidal properties. The studies were conducted on the culture of dental plaque. The observation period was 24 - 27 days. Further research was not possible due to the drying of wells with adhesives. Tantalum, aluminum, silver, vanadium, iron and copper nanoparticles were chosen as antimicrobial additives. It is shown that changing the mode of electric discharge dispersion-condensing device in a narrow range does not affect the antibacterial efficacy of the final product - the dental adhesive. It is found that tantalum nanoparticles increase the average value of shear strength in the system "filling material - adhesive - dentin" more than 40%.