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Toward Electronic Conductance Characterization of DNA Nucleotide Bases

Journal Solid State Phenomena (Volumes 121 - 123)
Volume Nanoscience and Technology
Edited by Chunli BAI, Sishen XIE, Xing ZHU
Pages 1387-1390
DOI 10.4028/www.scientific.net/SSP.121-123.1387
Citation Predrag S. Krstić et al., 2007, Solid State Phenomena, 121-123, 1387
Online since March, 2007
Authors Predrag S. Krstić, Jack C. Wells, Miguel Fuentes-Cabrera, Dong Xu, James Weifu Lee
Keywords Conductance, DNA, Electron Transport, Nanoelectronics, Nucleotides, Sequencing
Abstract

We calculate electron-transport properties within equilibrium, linear transport theory through the DNA nucleotide bases spanning two gold nanowires. Our quantum mechanical calculations show that single configurations of DNA bases A, C, T, and G have significantly different charge conductance characteristics. This result is consistent with the notion that it is possible to read the nucleotide base sequence on an individual DNA heteropolymer which is moving through a gap between electrically biased nanoelectrodes by measuring the changes in the electron-transport conductance.

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