Paper Title:
Controlled Drug Release Using Nanoporous Anodic Aluminum Oxide
  Abstract

Hardening of blood vessels has steeply increased every year, and implantation stent was used to solve that the conditions of illness. However, in-stent restenosis continues to make problem. To overcome the problem of in-stent restenosis, the concept of local delivery of antiproliferative or immunosuppressive drugs has been introduced into interventional cardiology. Local drug delivery system was demonstrated by using drug-eluting stents coated with nanoporous anodic aluminum oxide (AAO) used for controlled drug release. Effects of diameter and depth of AAO on the diffusion characteristics of drug were investigated. 2-deoxyadenosine was tested. AAO pore diameter and depth showed image by SEM and characterization of diffusion of drug from the AAO nanoporous pore diameter and depth was carried out using by HPLC (high performance liquid chromatography).

  Info
Periodical
Solid State Phenomena (Volumes 121-123)
Edited by
Chunli BAI, Sishen XIE, Xing ZHU
Pages
709-712
DOI
10.4028/www.scientific.net/SSP.121-123.709
Citation
H. J. Kang, S. J. Park, J. B. Yoo, D. J. Kim, "Controlled Drug Release Using Nanoporous Anodic Aluminum Oxide", Solid State Phenomena, Vols. 121-123, pp. 709-712, 2007
Online since
March 2007
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Price
$32.00
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