The chemical reaction between water and frit surface was determined using pH meter, ICP-MS, zeta-potential analyzer and FT-IR. With increasing the content of barium and boron of glass composition, the difference of water pH increased with different glass systems. During wet milling in aqueous solution, boron and barium of glasses dissolved. The values of zeta potential of lead and bismate frits were negative in water solution. Based on the results, when wet milling is used in water solution, the contents of barium and boron in a glass should be less than 10mol%.