The aim of this study was to determine the influence of powder fillers on the tribological properties of composite materials used for dental fillings. The investigated composites contain a fluoridated filler (based on Ba-Sr-Al-P-Na-silicate glass fillers) as a fluoride source as well as different powder fillers (friction modifiers) e.g. silicon nitride (Si3N4), boron nitride (BN), polyethylene (PE), polytetrafluoroethylene (PTFE). Composite disks were photo-cured and tested for wear against harder stainless-steel counterface. Wear tests were carried out by means of special tribotester in the presence of phosphate buffer as a lubricant. Influence of the load and filler contents on the friction coefficients and wear were estimated. The interaction between the filler particles and organic matrix and its influence on the tribological behavior of prepared specimens were observed. Organic powder fillers (PE, PTFE) reduced the friction coefficient and the wear of tested composite materials for dental fillings. Inorganic friction modifiers (Si3N4, BN) did not exhibit this effect.