As one of applications for Microstructured Optical Fiber, a new device for measurement of low gas concentration was designed. In the developed system the Photonic Bandgap Fiber (PBGF) was used as a gas cell. Proposed technique allowed reducing gas sample volume to 0.01 cc. The gas flow inside core of fiber was simulated and result was confirmed experimentally. During the experimental work several types of fibers of various parameters were specially designed, produced and used. Core diameters ranged from 10.9 μm to 700 μm. Various cutting techniques for fibers such as using the fiber cleaver, Focused Ion Beam and Cross Section Polisher were investigated.