Paper Title:
Electrically-Controlled Penicillin/Streptomycin Release from Nanostructured Polypyrrole Coated on Titanium for Orthopedic Implants
  Abstract

Implant infection leading to revision surgery can be avoided by incorporating controllable antibiotic release from titanium (Ti) implant surfaces. In this study, penicillin/streptomycin (P/S) and dexamethasone (Dex) were successfully immobilized via electropolymerization within polypyrrole membranes coated on the surface of Ti, which is widely used in orthopedic applications. In vitro results showed that greater numbers of osteoblasts adhered on these polymer-coated substrates than on currently-used unmodified Ti. X-ray photoelectron spectroscopy was used to monitor and compare the reaction effectiveness and the yield of electropolymerization. Polypyrrole membranes conjugated with P/S and Dex, and then coated with PLGA, all possessed nanometer scale roughness, as analyzed by atomic force microscopy. In summary, this study demonstrated that drugs incorporated within electroactive polypyrrole membranes, whose release was controlled by applying voltages, supported osteoblast adhesion and could potentially fight bacterial infection.

  Info
Periodical
Solid State Phenomena (Volume 151)
Edited by
Erich Kny
Pages
197-202
DOI
10.4028/www.scientific.net/SSP.151.197
Citation
S. Sirivisoot, R. A. Pareta, T. J. Webster, "Electrically-Controlled Penicillin/Streptomycin Release from Nanostructured Polypyrrole Coated on Titanium for Orthopedic Implants", Solid State Phenomena, Vol. 151, pp. 197-202, 2009
Online since
April 2009
Export
Price
$32.00
Share

In order to see related information, you need to Login.

In order to see related information, you need to Login.

Authors: Noriko Kotobuki, Daisuke Kawagoe, Hirotaka Fujimori, Seishi Goto, Koji Ioku, Hajime Ohgushi
1055
Authors: Akiko Obata, Toshihiro Kasuga
Abstract:Cellular activities of human mesenchymal stem cells (MSCs) and osteoblasts (HOBs) on a silicon-releasable scaffold, which is siloxane-doped...
399
Authors: Noriko Kotobuki, Motohiro Hirose, Koji Ioku, Akira Sakaguchi, Akifumi Iwama, Masaki Harada, Hiroshi Yamamoto, Hajime Ohgushi
Abstract:Since 2001, we have clinically utilized human bone marrow-derived mesenchymal stem cells (MSCs) for bone regeneration. The osteogenic...
997
Authors: Wan Ting Niu, Lu Yao Zhang, Min Pan, Yu Quan Chen
Chapter 3: Chemical and Biomedical Engineering
Abstract:Superparamagnetic iron oxide (SPIO) nanoparticles were used more and more universally in biomedical research recently. In order to develop a...
1089
Authors: Nomaphelo Ntshongontshi, Abd Almonam A. Baleg, Rachel Fanelwa Ajayi, Candice Rassie, Ezo Nxusani, Lindsay Wilson, Usisipho Feleni, Unathi Sidwaba, Sinazo Qakala, Samantha F. Douman, Priscilla Gloria Lorraine Baker, Emmanuel Iheanyichukwu Iwuoha
Abstract:HIV and AIDS are among the world’s pandemics that pose serious concern to almost every individual in the world. With the current level of...
265