Paper Title:

The Characterization of Ketoprofen-Hydroxypropyl–β-Cyclodextrin Complex with Modified Drugs Release Properties

Periodical Solid State Phenomena (Volume 188)
Main Theme Advanced Materials and Structures IV
Edited by Mircea Nicoară, Aurel Răduţă and Carmen Opriş
Pages 70-75
DOI 10.4028/www.scientific.net/SSP.188.70
Citation Monica Cretan Stamate et al., 2012, Solid State Phenomena, 188, 70
Online since May, 2012
Authors Monica Cretan Stamate, Carmen Gafitanu, Ciprian Stamate, Eliza Gafitanu
Keywords Extended Release Tablets, Ketoprofen-Cyclodextrin Complex, Solubility, Wear Resistance
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Abstract

Since, anti-inflamatory drugs have a high demand due to increased incidence of pain associated with different pathology; the objectives of this paper are the synthesis, the physicochemical characterization and analysis of the tribological properties for the ketoprofen-cyclodextrin complexes. The analysis of solubility for these complexes was carried out using MathCAD software. Tribological factors were evaluated by the wear resistance of cylindrical tablets containing ketoprofen-cyclodextrin complex, methocel and magnesium stearate. The tablets with ketoprofen-cyclodextrin complexes provide good solubility and wear resistance and these are ideal for preparation of extended release systems like implantable tablets or for orally administration tablets.