The Characterization of Ketoprofen-Hydroxypropyl–β-Cyclodextrin Complex with Modified Drugs Release Properties
| Periodical | Solid State Phenomena (Volume 188) |
|---|---|
| Main Theme | Advanced Materials and Structures IV |
| Edited by | Mircea Nicoară, Aurel Răduţă and Carmen Opriş |
| Pages | 70-75 |
| DOI | 10.4028/www.scientific.net/SSP.188.70 |
| Citation | Monica Cretan Stamate et al., 2012, Solid State Phenomena, 188, 70 |
| Online since | May, 2012 |
| Authors | Monica Cretan Stamate, Carmen Gafitanu, Ciprian Stamate, Eliza Gafitanu |
| Keywords | Extended Release Tablets, Ketoprofen-Cyclodextrin Complex, Solubility, Wear Resistance |
| Price | US$ 28,- |
Since, anti-inflamatory drugs have a high demand due to increased incidence of pain associated with different pathology; the objectives of this paper are the synthesis, the physicochemical characterization and analysis of the tribological properties for the ketoprofen-cyclodextrin complexes. The analysis of solubility for these complexes was carried out using MathCAD software. Tribological factors were evaluated by the wear resistance of cylindrical tablets containing ketoprofen-cyclodextrin complex, methocel and magnesium stearate. The tablets with ketoprofen-cyclodextrin complexes provide good solubility and wear resistance and these are ideal for preparation of extended release systems like implantable tablets or for orally administration tablets.