Papers by Author: H. Marcal

Abstract: Extracellular matrices (ECM) derived from urinary bladder membrane (UBM) have demonstrated substantial potential for applications in tissue repair and reconstruction. However, these materials are limited by the requirement of suturing following surgery. In this paper, the coalescence of UBM with an advanced surgical adhesive demonstrated a suitable alternative to sutures for wound closure, prevention of fluid leakage and improvement of cell growth. This novel bioadhesive contains favourable characteristics that are suitable for tissue repair, support of cell growth, and influence cellular microenvironments that are biocompatible with peripheral nerve regeneration in the spinal cord.

Abstract: Laser activated SurgiLux^® technology was examined to determine its suitability as an ocular wound sealant. SurgiLux showed suitable strength and flexibility as well as moisture content for applications in the eye. In comparison to conventional microsuturing complemented with fibrin sealant, application of the SurgiLux technology was up to 5 times faster and the strength of the repaired wounds up to 7 times greater, with a 6 mm incision withstanding 235 mm Hg pressure compared to 120 mm Hg for sutures with fibrin.