Papers by Author: Tsung Shune Chin

Abstract: The oxidation behavior of Y56Al24Co20 bulk metallic glass containing ~4.2% Y-rich particles was studied over the temperature range of 325-450oC in dry air. The results showed that the oxidation kinetics of the alloy followed the parabolic rate law at T≤375oC, with rate constants generally increased with temperature. Conversely, para-linear kinetics were observed at higher temperatures (T≥400oC). The scales formed on the Y-base amorphous composite were temperature dependent, consisting of exclusively yttrium oxides (Y2O3) at T≤375oC and of mostly Y2O3 and alumina (Al2O3) at temperatures. No evidence of any cobalt-containing oxide was found in the scale.

Abstract: Radiotherapy is one of the effective treatments for cancers. This study presents a potential internal radiotherapy drug, radioactive calcium-phosphate micron-sized particles (RCPMP). The interaction of calcium-phosphate micron-sized particles (CPMP) with hepatoma cells and the cytotoxicity of RCPMP to hepatoma cells were evaluated. The CPMP having the eutectic composition of the CaO-P2O5 system (CaO-47wt% P2O5) was prepared and subsequently subjected to neutron irradiation in a nuclear reactor to yield RCPMP. The main nuclide in the RCPMP was P-32. RCPMP could be stably retained in a serum and culture medium. These CPMP had a high affinity with HepG2 human hepatoma cells. Cells climbed onto the larger CPMP particles, surrounding and embedding them within several days. The submicro-sized CPMP were endocytosed and retained in HepG2 cells. The dose dependent killing effect was obtained in RCPMP treated HepG2 cells. Cells were killed and detached from the flask with little morphological changes under a high dosage of RCPMP treatment. Meanwhile, treating HepG2 cell cultures with a lower dosage of RCPMP led to morphological changes before cell death. This RCPMP was biocompatible and had high killing effect on hepatoma cells.