Papers by Author: Xi Ming Pu

Abstract: 5-Fluorouracil-poly(L-lactide) (5-Fu-PLLA) microspheres have been co-precipitated in a process namely solution-enhanced dispersion by supercritical CO2 (SEDS). First, the 5-Fu is successfully micronized and then used to produce the 5-Fu-PLLA microspheres. The 5-Fu-PLLA microspheres synthesized in the SEDS process exhibited a rather spherical shape, smooth surface, and a narrow particle size distribution, where it ranged from 531 nm to 1280 nm, with a mean particle size of 793 nm. The dichloromethane residue in the 5-Fu-PLLA microspheres is 46 ppm. The average drug load of the 5-Fu-PLLA microspheres is 12.7%. The results of this study indicate that the SEDS process is an effective technique to co-precipitate 5-Fu and PLLA as composite microspheres.

Abstract: To increase the mechanical properties of PLA used for fracture inner fixation, β-calcium metaphosphate whiskers were prepared by controlled crystallization in the glass. The factors influencing the morphology of the samples, such as component, time and temperature of crystallization were discussed. Results showed that the high quality of β-calcium metaphosphate whiskers can be obtained by crystallization treating for 36 hours and washing for 48 hours at 80°C distilled water. β-calcium metaphosphate whiskers having high aspect ratios of 20-100 with diameters of 1-5μm were achieved at the optimized conditions.