Papers by Author: Zheng Fu

Abstract: A novel type of chiral methacrylamide derivative, N-[o-(4-phenyl-4,5-dihydro-1,3-oxazol-2-yl) phenyl]methacrylamide ((R)-PhOPMAM), was synthesized and radically polymerized to the corresponding polymers in moderate yields. The polymerization characteristics and the chiroptical behavior of the resultant polymers have been examined in detail by using IR and ¹H NMR spectroscopies in comparison with our previous observation. The polymers showed relatively high molecular weights(Mn=5000-10000) and large specific rotations([α] ₂₅^D = -326.0°～-357.4°).

Abstract: The radical polymerization of optically active methacrylamide derivatives, N-[o-(4-phenyl-4,5-dihydro-1,3-oxazol-2-yl) phenymethacrylamide ((R)-PhOPMAM) and N-[o-(4-isopropyl-4,5-dihydro-1,3-oxazol-2-yl) phenymethacrylamide ((S)-PrⁱOPMAM), were carried out under various conditions. The effect of the Lewis acid, that is, rare earth metal trifluoromethanesulfonates on the free-radical polymerization were examined under different solvents. The Lewis acids are effective in enhancing the isotacticity in the polymerization of (S)-PrⁱOPMAM. The same phenomenon were not happened in the polymerization of (R)-PhOPMAM. The polymerization characteristics and the chiroptical behavior of the resultant polymers have been examined by using circular dichroism (CD), UVVis, and NMR spectroscopies.

Abstract: The radical polymerization of optically active methacrylamide derivative, N-[o-(4-isopropyl-4,5-dihydro -1,3-oxazol-2-yl)phenyl] methacrylamide ((S)-MeOPMAM), was carried out under various conditions. The effect of Lewis acid, that is, rare earth metal trifluoromethanesulfonates on the free-radical polymerization were examined under different solvents. The polymerization in the presence of rare earth metal trifluoromethanesulfonates produced isotactic-rich polymers compared with those obtained without the Lewis acid. The polymerization characteristics and the chiroptical behavior of the resultant polymers have been examined by using circular dichroism (CD), UV–Vis, and NMR spectroscopies.

Abstract: A new O/W microemulsion system for transdermal matrine delivery was developed in order to provide clinical medication of matrine with a more convenient,reasonable and effective new form.Various factors were investigated including solubility of matrine,the skin permeability of matrine in various components, and the compatibility among surfactants, cosurfactants and oils, aiming to choose suitable surfactants, cosurfactants and oils.The pseudo-ternary phase diagrams were constructed to determine the concentration ratio of components in the microemulsion. The formulation of microemulsion was optimized by using the simplex lattice method.The optimum formulation with the highest skin permeation rate (1239.56 μg /cm²/h) consisted of 7.2% matrine,4.5% ethyl oleate- ethyl butyrate(4:1), 23 % EL-OP(1:1) ,15 % PEG-400 and water.