Papers by Keyword: β-Cyclodextrin

Abstract: In this study, the starch-based material β-cyclodextrin was used as the original material to substitute petrochemical product-polyoxyethylene (HPEG) to synthesize concrete admixture polycarboxylate superplasticizer (PCE). During the synthesis, β-cyclodextrin was first grafted on the PEO chain to prepare β-CD-HPEG by click reaction. Then β-CD-HPEG was used to substitute the macromonomer HPEG to synthesize β-CD-PCE. When the substitution amount HPEG was 3%, the synthesized β-CD-PCE showed better dispersion ability.

Abstract: Orodispersible films (ODFs) is orally pharmaceutical dosage form that rapidly disintegrates and instantly releases the drug when placed on the tongue. This study was firstly aimed to investigate physicomechanical properties of ODFs containing diclofenac sodium/β-cyclodextrin (DS/βCD) inclusion complexes prepared by solvent casting method. The influence of plasticizer, βCD and DS on hydroxypropyl metlhycellulose (HPMC) film was studied. Increasing of plasticizer concentration (e.g. PEG400 amd glycerol) resulted in decrement of disintegration time, strength and elasticity of HPMC films. When βCD was incorporated, opaque films were observed. Presence of βCD resulted in degrading of physicomechanical properties, except percentage of elongation representing the film’s elasticity. βCD films containing DS (DS/βCD films) were more brittle and transparent than blank βCD films. Amount of incorporated DS influenced on disintegration time and strength of obtained films. Cross-section scanning electron microscope (SEM) photomicrographs showed spherical particles scattered on DS/βCD films illustrating the occurrence of DS/βCD inclusion complexes during casting process. The DS/βCD inclusion complexes were then confirmed in both solid and solution. Furthermore, DS/βCD ODFs were prepared by incorporation of artificial sweeteners in DS/βCD films. It was found that DS/βCD ODFs containing xylitol were more brittle and their disintegration times were faster then those containing sucralose. Dissolution profiles were investigated then reported that release kinetic of DS/βCD films and ODFs were fitted to Higuchi model. In summary, the βCD-based ODFs containing DS were successfully developed.

Abstract: The worm-like morphology of silver sulfide (Ag₂S) was successfully prepared via hydrothermal reaction at 150°C by using silver nitrate (AgNO₃) and thioacetamide(CH₃CSNH₂) as both the sliver sources and sulfur sources, β-cyclodextrin as the template agent, and water as the solvent. The worm-like of Ag₂S are characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), x-ray diffraction (XRD), x-ray photoelectronspectroscopy (XPS), energy dispersivex-ray (EDX), high-resolution transmission electron microscopy (HRTEM) and selected area electron diffraction (SEAD). Ultraviolet-visible spectra (UV-vis) and photoluminescencespectroscopy (PL) were used in an optical study of the products. The results showed that the existence of β-cyclodextrin is crucial to the formation of worm-like Ag₂S, and the optoelectronics test results showed that the sample have a broad absorption in ultraviolet and visible light region.

Abstract: β-Cyclodextrin polymer were prepared by inverse-phase suspension polymerization using epichlorohydrin (EPI) as crosslinker. The architecture has been characterized by Fourier transform infrared spectra (FT-IR) and thermogravimetric analysis (TGA), which confirmed that cyclodextrin polymer have been synthesized successfully. β-Cyclodextrin polymer (EPI-CD) can interact with a variety of hydrophobic compounds to form inclusion complexes, such as phenol. Experimental results indicated that the adsorption reached to 58.51umol/g under the initial concentration of 120mg/L at 298K. The adsorption isotherm was fitted to the Langmuir and Freundlich models. From the experimental data, it may be inferred that EPI-CD polymer was an effective adsorbent for the removal of phenol in wastewater treatment.

Abstract: Inclusion complex of β-cyclodextrin (β-CD) and Plai (Zingiber cassumunar) oil was prepared using a simple co-precipitation method at β-CD to Plai oil in different ratios. The inclusion complexes were characterized using Fourier transform-infrared spectroscopy (FT-IR) and differential scanning calorimetry (DSC). The FT-IR absorption bands of inclusion complex at 3600-3200 cm^-1 were broader and shifted toward lower frequencies compared with that of pure β-CD (3359 cm^-1). DSC of the inclusion complexes showed two endothermic peaks shifted to lower temperatures (90-100°C and 295-300°C) compared to that of β-CD. The different physicochemical characteristic could be an indication of an embedded guest molecule in the β-CD cavities in the inclusion complex preparation.

Abstract: To study the process conditions for preparing aspirin β-cyclodextrin inclusion.Method: Choose the usage ration of aspirin with β-cyclodextrin and the time of reaction as the main factors, and use the inclusion yield as evaluated indicators and the process condition to conduct orthogonal experiment Optimization Pack aspirin.Outcome: The optimum inclusion process condition: molar ratio of the aspirin with β-cyclodextrin is 1:3, inclusion time is 60 minutes.Conclusion: The process condition of using β-cyclodextrin inclusion to inconcluse aspirin is feasible, effective, and of applicative value.

Abstract: To study the process conditions for preparing sultamicillin tosilate β-cyclodextrin inclusion.Method: Choose the usage ration of sultamicillin tosilate with β-cyclodextrin, the inclusion temperature and the time of reaction as the main factors, and use the inclusion yield as evaluated indicators and the process condition to conduct the L⁹ (3⁴) orthogonal experiment Optimization Pack sultamicillin tosilate.Outcome: The optimum inclusion process condition: molar ratio of the sultamicillin tosilate with β-cyclodextrin is 1:8, inclusion temperature is 47°C, inclusion time is 40 minutes.Conclusion: The process condition of using β-cyclodextrin inclusion to inconcluse sultamicillin tosilate is feasible, effective, and of applicative value.

Abstract: The inclusion complex of β-cyclodextrin (β-CD) and dibutyl phosphite (T304) was prepared by trituration. The tribological properties of the complex with different concentrations were investigated by a four-ball tester in the solution of polyethylene glycol-600 (PEG-600). The tribological test results showed that the complex exhibited better anti-friction and anti-wear properties than β-CD under different loads, and it was noted that the tribo-system showed the least friction coefficient when the concentration of the complex was 0.9%. It was proposed that the complex was decomposed into various molecular fragments and the T304 molecules were released under the friction condition. The XPS analytical results on the worn surfaces revealed that phosphide film formed by the released T304 played a major role and the iron alkoxide and carbon deposition films formed by the β-CD fragments had better anti-friction effect on the phosphide film surface. The interactions of different films resulted in the formation of a mixed boundary lubrication film.

Abstract: In the paper, the molecular engram polymer is produced by dithizone which is functional monomer,β-cyclodextrin which is pore-forming material and chloroepoxy propane which is crosslinking agent. Atomic absorption method is used to study its adsorption for lead. Thermodynamic model of adsorption and dynamic reaction order are discussed. The results show that adsorption is endoergic process and accords with Freundlich isothermal adsorption equation. Adsorption system conforms with pseudo-second order dynamic model, the static saturation adsorption amount is 45.55mg/g.

Abstract: The mono-(6-p-toluenesulfonyl)-β-cyclodextrin was firstly synthesized fast and efficiently by adopting ultrasound assisted method in alkaline water solution. The reaction time was only 40 min but with the yield of 31.1% under ultrasound condition. Compared with the conventional synthetic methods, the proposed novel method could shorten the reaction time and improve the yield. It is a simple, rapid and efficient method.