Papers by Keyword: 2-Hydroxyethyl Methacrylate

Abstract: The coating property of (meth) acrylate copolymer with gradient wettability surfaces was studied. The random (meth) acrylate copolymers can be obtained according to the free radical polymerization method and their coating property was analyzed according to performance testing. The gradient wettability surface was prepared by using the sodium hydroxide solution. The effects of the kinds of crosslinking monomer, mass ration of HEMA, additional method of HEMA, amount of curing agent and curing temperature on the coating property of (meth) acrylate copolymer were discussed. It was found that the mass ration of HEMA was 15 % and the additional method of HEMA was added previously when the molar ration of MMA/BA was 6/4. The amount of curing agent was 1.86 g and the curing temperature was 160 °C when the P (MMA-BA-HEMA) solutions were 10 g.

Abstract: Controlled release studies of drugs (theophylline (TH), fenethylline hydrochloride (FE) and gentamicin sulphate (GS)) from pH sensitive poly(2-hydroxyethyl methacrylate/itaconic acid) (P(HEMA/IA)) hydrogels obtained by gamma irradiation were carried out to investigate transport phenomena. Drug behavior and release profiles were analyzed using the restriction coefficient combining the influence of network structure and the size of the drug on release and transport properties. The results demonstrated that the ratio of drug radius to polymer pore size and drugpolymer interactions were dominant factors in hindering the diffusion process. The diffusivity of a drug through the hydrogels decreases with the size of the drug molecules and with the decrease in gel pore size. The diffusion equations for used drugs explain drug transport in hydrogels.