Papers by Keyword: Aldol Condensation Reaction

Abstract: This research focuses on the synthesis and evaluation of the antibacterial activity of the compound cinnamylideneacetophenone, achieved through an aldol condensation reaction using cinnamaldehyde as the aromatic aldehyde and 2-acetylnaphthalene as the aromatic ketone. The primary objective of this study was to successfully synthesize cinnamylideneacetophenone and assess its antibacterial properties against specific bacterial strains. The synthesis resulted in a yield of 89.15%, and the synthesized compound was characterized using Fourier Transform Infrared Spectroscopy (FTIR) and Nuclear Magnetic Resonance (NMR) to confirm its structural integrity. Following characterization, the target compound was identified as 1-(2-naphthyl)-5-phenyl-2,4-pentadien-1-one. However, when tested for antibacterial activity using the agar diffusion method against Staphylococcus aureus and Escherichia coli, the results indicated that the synthesized chalcone analog exhibited weak antibacterial properties, with an inhibition zone diameter of less than 5 mm. In conclusion, while cinnamylideneacetophenone was successfully synthesized and characterized, its antibacterial activity was limited, suggesting further research to explore modifications that could enhance its efficacy as an antibacterial agent.

Abstract: Nitridation of amorphous aluminium phosphate (AlPO4) and mixed aluminium gallium phosphate (Al0.5Ga0.5PO4) under ammonia flow allows preparing “AlPON” and “AlGaPON” bifunctional acid-base heterogeneous catalysts. Their acid-base bi-functional character allows their use as selective catalysts for the production of jasminaldehyde through the cross-condensation of heptanal and benzaldehyde, followed by the dehydration of the aldol intermediate product. Three parameters enabling to maximize the jasminaldehyde yields in a batch reactor operated at 125°C were investigated: the catalyst composition (Al/Ga and O/N ratio), the reactant concentration and the amount of catalyst in the reactor. Maximum jasminaldehyde selectivities were obtained for intermediate nitrogen contents (7-10 wt.%). Maximum reaction rates were obtained using pure reactants and a catalysts weight equal to 10% of the total reagent weight.