Papers by Keyword: Bioactive Titanium

Abstract: The paper presents a simple chemical treatment to provide various non-metallic substrates such as polypropylene or polyethylene with in vitro bioactivity or ability to deposit apatite in SBF. Anatase/rutile dual layers were deposited at low temperature on the substrates when they were soaked in TiOSO4/H2O2 solution and aged in hot water: The dense bottom layer predominantly consisted of rutile, while the upper layer consisted of loosely packed aggregation of anatase particles. The titania deposition was the results of compromise among two conflicting processes: 1) hydrolysis of TiOSO4 to yield either soluble titania-H2O2 complexes or titania, and 2) dissolution of the titania layer under the presence of H2O2. The dissolution-deposition equilibrium was found associated with pH of the sulfate solution. Thus, proper pH value in the treating solution was the key factor to control the formation of dense titania layers. The resulted titania layers were easily covered with fine apatite particles when soaked in SBF supersaturated with its component ions.

Abstract: Titanium has limitations in its clinical performance in dental and orthopaedic applications. Over the last decade, numerous implant surface modifications have been developed and are currently used with the aim of enhancing bone integration. In the present study, we have experimented a bioactive titanium prepared by a simple chemical and moderate heat treatment that leads to the formation of a bone-like apatite layer on its surface in simulated body fluids. We haved used foetal rat calvaria cell cultures to investigate bone nodule formation on bioactive titanium. Scanning electron microscopy (SEM) showed that cells attached and spread on the bioactive surfaces. After 22 days of culture, bone nodules were detected on the material surface. Furthermore, the mineralized bone nodules remained attached to the bioactive titanium surface but not to untreated titanium. SEM observations and EDX microanalysis of sectioned squares showed that bone-like tissue directly bonded to bioactive titanium, but not pure titanium. These results indicated the importance of the implant surface composition in supporting differentiation of osteogenic cells and the subsequent apposition of bone matrix allowing a strong bond to bone. Furthermore, these findings may provide promising strategies for the development of biologically active implants.

Abstract: The bioactivities of titanium oxide film on titanium surface received from different chemical treatment methods were studied in SBF in vitro and mechanically and histologically investigated in vivo. Three groups of titanium specimens were prepared: untreated titanium(S), acid-alkali treated titanium (H), and acid-alkali and heat-treated titanium(X). The oxide film of X surface resulted in more apatite formation and significantly higher strength of the interface between the samples and bone than those of the other titanium groups. The surface of the acid-alkali treated titanium and that further treated by heat treatment had higher bioactivity and stronger bone-bonding ability.