Papers by Keyword: Bioglass

Abstract: The 45S Bioactive glass-ceramic (BG) and Chromium (Cr)-doped BG materials were successfully produced in this study. XRD, FTIR, and ICP-MS techniques were used to characterize the prepared materials. The XRD testing showed that all samples contained pure BG. Increased Cr ion inclusion shifted the BG diffraction peaks to a lower value of 2 Theta and increased crystallinity. FTIR was used to detect Si-O, P-O, and Ca-O functional groups. Cr ions steadily decreased the Ca-vibration mode area. The ultraviolet-visible spectrophotometry was used to measure the optical characteristics of pure and Cr BG-doped materials. The Cr-doped BG was green in colour, whereas the lab-synthesized BG was white. Two additional bands formed at 433 and 615 nm when Cr ions were doped into the BG structure. These bands may be caused by ⁴A₂ → ⁴T₁ and ⁴A₂ → ⁴T₂ electronic d-d transitions. The findings show that biomedical applications may exist for fluorescent probes manufactured from Cr-BG materials.

Abstract: Bioactive glass use silica (SiO₂), calcium carbonate (CaCO₃), sodium carbonate (Na₂CO₃), phosphorus pentoxide (P₂O₅) as raw materials. In this work, bioactive glass (BG); 45S5 bioactive glass was synthesized using natural resources materials; rice husk ash (RHA) as silica (SiO₂) source and seashell (SS) as calcium carbonate (CaCO₃) source through melt derived method. All raw materials were melted at 1400 °C and water quenched. The glass frit obtained was milled and sieved then analyzed using X-ray diffraction (XRD), Fourier Transform Infrared spectroscope (FTIR) and Scanning Electron Microscope (SEM). The mechanical properties 45S5 BG pellet was observed through diametral tensile stress (DTS). The XRD and FTIR pattern for all sample synthesized using natural resources raw materials show similar pattern with control sample 45S5 synthesis using pure raw materials. The mechanical properties for all samples also have not significantly different with control samples

Abstract: Strontium (Sr) stimulates osteoblast and inhibits osteoclast activities in-vitro and is used clinically as a treatment for osteoporosis. In this research, the effect of Sr substitution on the apatite formation of sol-gel derived bioactive glass (BG) (55.90SiO₂-1.72P₂O₅ -21.67Na₂O - (20.69-x) CaO -x SrO) (x=0, 5 and 8 mol. %) were investigated. The synthesized Sr doped BG samples were treated in Hank's Balanced Salt Solution (HBSS) for 14 days to study the bioactivity. The achieved samples were evaluated by X-ray powder diffraction (XRD) and Scanning electron microscope (SEM). In XRD, the hydroxyapatite (HA) crystalline peak for 8% Sr-BG is less compared with others. When Sr amount is increased to 8%, the low crystalline peaks of HA were detected although the same soaking duration. FTIR spectra supported the delay precipitation of calcium phosphate (CaP), especially for the specimen containing 8% Sr. After 14 days soaking, SEM images confirmed the bioactivity of the synthesized samples by the formation of apatite on the glass surface.

Abstract: This paper deals with the development of button made from a hydroxyapatite (HA) and bioglass composite. The HA powder derived from the bovine bone were added 2.5 and 5 wt% of P₂O₅-CaO-Na₂O-bases glass and subsequently sintered at 1200 - 1350 °C to form the HA ceramics. It was observed that the densest HA ceramic could be achieved for the sample composed of hydroxyapatite with the addition of 5 wt% of bioglass and sintered at 1300°C, resulting in the maximum value of bending strength of about 77 MPa, which ensured the use in load bearing applications of this HA ceramic. The HA and 5 wt% bioglass composite is designed as a button for reattach the bone flap after a craniotomy procedure. Each device is comprised of an inner plate and an outer plate. The fabrication processing was used the powder compression and then sintering at 1300°C for 3 h. The button have fracture toughness (K_1C) values of 1.3±0.1 MPa.m^1/2 and bending strength of 65.7±3.8 MPa. The liquid phase sintering of this sample contributed to the high mechanical properties that can be use as craniotomy flap fixation.

Abstract: In this work, the thermal treatment temperature effect on phase formation and bioactivity of glass-ceramics based on the SiO₂-Na₂O-CaO-P₂O₅ system has been studied. The chemical composition of the system is 45 wt.% SiO₂, 24.5 wt.% Na₂O, 24.5 wt.% CaO and 6 wt.% P₂O₅ (45S5). The rice husk ash is used as the natural raw materials instead of commercial SiO_2. All of the investigated compositions were prepared by melting the glass mixtures at 1350°C for 3 h. The resulting glass samples were heated at different thermal treatment temperatures ranging from 750 to 1050°C with fixed dwell-time for 4 h for crystallization. Phase identification of the 45S5 glass ceramics was carried out by X-Ray diffraction (XRD). Moreover, the physical properties such as density, porosity and mechanical properties were systematically investigated. It was found that, the increasing of heat treatment temperature led to the increasing of the Na₂Ca₂Si₃O₉ phase and obtaining better bioactive behavior after incubation of glass-ceramics in simulated body fluid (SBF) for 7 days. The maximum hardness value of 4.02 GPa was achieved after heating at 1050°C for 4 h. However, the density value has slightly changed with various heat treatment temperatures.

Abstract: In this work, the nucleation of bioglasses particles was approached through Dynamic Light Scattering in order to analyze how different synthesis parameters influence on the particle growth. It was evaluated the following parameters: pH between 10 and 11; surfactant concentration (PEG) between 0 to 20g/L; Three different compositions were chosen based on the 47SiO₂-(38 – x)Na₂O-(9 + x)CaO-6P₂O₅ system ( x = 0, 10 and 20). For each experimental condition, the growth kinetics (Kc.t^-1) was calculated, and the obtained values were analyzed by factorial design of experiments. The results evidence that higher pH, higher surfactant concentration and lower Na/Ca ionic ratio lead to lower values growth kinetics in which, in turn, are associated with lower particle size.

Abstract: Magnesium and bioglass are a good combination to create biocompatible and bioactive materials. Magnesium-bioglass composites can be manufactured by casting or sintering. This work was aimed to manufacture the composite Mg-3wt.%Zn filled with 5, 10, 15, 20, 25 and 30wt.% bioglass (45S5) by powder metallurgy. Two sintering temperatures of 450 °C and 550 °C were used to sinter the samples. The sintered samples were characterized using optical micrograph and X-Ray diffraction (XRD). Optical micrograph shows that increasing of bioglass content lead to smaller grain size. XRD analysis shows no new crystalline compound detected on XRD pattern for Mg-3wt%Zn sintered at 450 °C ad 550 °C.

Abstract: The biomaterials are used for many biomedical applications. The main objective of the present work was to investigate the potential role of Bioglass (Melting)- Polyvinyl alcohol (BG (M)-PVA) and Bioglass (Melting)-Polyvinyl alcohol-20%Ciprofloxacin (BG (M)-PVA-20Cip) in regenerative bone capacity. These composites were implanted in the femoral condyles of Wistar rats and compared to that of ovariectomised groups. Our results noted, after the different period of implantation (15, 30, 60 and 90 days), that the Alkaline phosphatase (ALP) and Acid phosphatase (ACP) activities showed an excellent osteoinductive property of BG (M)-PVA, that this phenomena decreased with the presence of ciprofloxacin. Physico-chemical techniques (ICP-OES and SEM) were engaged to highlight the influence of antibiotic on the structure, porosity and bioactivity of a porous Glass-PVA before and after implantation. The results obtained by ICP-OES showed a rapid reduction in silicon (Si) and sodium (Na), and noted an accelerator increase in calcium (Ca) and phosphorus (P) ion concentrations in BG (M)-PVA that the BG (M)-PVA-20Cip. This result is confirmed by SEM. We can conclude that the loading of ciprofloxacin in BG (M)-PVA is characterized by a retard effect of formation of apatitic phase.

Abstract: In this work, attention was paid to the understanding of the chemical modifications occurring in xerogeis of 58S bioglass (60% mol SiO₂; 36%mol CaO; 4%mol P₂O₅), during the 58S bioglass synthesis, prepared by the sol-gel (SG) and sol-gel self-propagating combustion (SGSPC) methods using citric acid as reductant/fuel. The chemical modifications of the xerogels were evaluated in the temperature range 70-920°C. Characteristic functional groups were evidenced by Fourier transform infrared spectroscopy (FTIR), and the thermal behaviour was evidenced by thermal gravimetric (TG) and differential thermal (DSC) analysis, the transition from glass to glass ceramic was also followed by X-ray diffraction.

Abstract: Bioglass is a good bioactive material and has been used in many medical fields, include drug delivery systems, non-load-bearing implants and bone cements. Sol-gel is a good method in the preparation of coating materials. It also can be used in the preparation of bioactive glass. In this paper, the principles and technical processes are introduced. The effects on characteristics of bioactive glasses of the factors such as H₂O dosage, ethanol dosage, gel temperature and activator are analyzed in detail. The research progress in preparation of sol-gel bioactive glasses is summarized. Finally the development foreground of sol-gel bioglass is also expected.