Papers by Keyword: Biointerface

Abstract: The vapor-phase deposition of 11-azidoundecyltrimethoxysilanes at reduced pressure and elevated temperature allows the introduction of azido (N₃) functionalized silicon wafer substrates. This process can be optimized by controlling the amount of surface adsorbed water and results in uniform and reproducible self-assembled monolayers (SAMs). The N₃-SAM density as investigated via TOF-SIMS is comparable on thermal oxide and Si₃N₄ substrates. Furthermore, it is demonstrated that biomolecules can be successfully conjugated on both substrates using azide-alkyne ‘click’ reactions.

Abstract: The phospholipid molecule is one of the typical components of the cell membrane. In particular, the phosphorylcholine polar group is an electrically neutral head group. Arrangement of phospholipid polar groups and construct the surface, we applied 2-methacryloyloxyethyl phosphorylcholine (MPC) polymers bearing a phosphorylcholine group in side chain, which was designed with the cell membrane as an inspiration. Versatile polymers comprising MPC could be synthesized, and their specific biofunctions were evaluated. Establishing an ultimate interface between biological circumstances and artificial materials, so-called biointerfaces, with multiple functions is important from the viewpoint of biomaterials science. Nonspecific protein adsorption is essential for achieving versatile biomedical applications. Simultaneously, bioconjugation and retention of its biofunction are crucial for a high-performance interface. In this article, we would like to introduce effectiveness of interface with highly biological functions composed of the MPC polymers for constructing nanobiodevices and nanomedicine.