Papers by Keyword: Bovine Derived Hydroxyapatite

Abstract: We evaluated the bone healing effect of grafting with synthetic β-tricalcium phosphate (β-TCP; Cerasorb®), bovine-derived hydroxyapatite (HA; Bio-Oss®), and a mixture of β-TCP and HA in rats. Each material was grafted in prepared 8-mm frontal bone defects in 15 rats. The control group underwent surgery without any grafting materials and was examined after 4 weeks, whereas the experimental groups received grafting materials and were examined after 1, 2, and 4 weeks. After implantation, the rats were sacrificed for histomorphometric studies using light microscopy, and the data were analyzed using analysis of variance. Considerable inflammation and fibrosis were observed after 1 and 2 weeks in all experimental groups, whereas the inflammation was reduced and fibrosis was stabilized after 4 weeks. New bone formation was observed at the defect margin. Statistically, there was no difference in new bone formation among the three experimental groups. In conclusion, there was no difference in new bone formation using Bio-Oss®, Cerasorb®, and a mixture of Bio-Oss® and Cerasorb®.

Abstract: The aim of this study was to prepare high performance biomaterials suitable for use at load bearing applications with high bioactivity. The hydroxyapatite (HA) was prepared from bovine bones via calcination technique. The bovine derived HA (BHA) was mixed with 5 and 10 wt% metallic titanium (Ti) and the obtained homogenous mixtures were pressed to produce the test samples. The compacts were sintered at temperatures between 1000 and 1300°C. Compression strength, density, and microhardness were measured. SEM and X-ray diffraction studies were also made. The best mechanical properties were obtained between after sintering at 1200-1300°C.

Abstract: In this study, hydroxyapatite (HA) material, obtained from calcinated bovine bone (BHA), was mixed with 0.25, 0.50, 1.00, and 2.00 wt% Li2CO3. The pressed pellets were sintered at various sintering temperatures between 900°C and 1300°C. Measurements of compression strength, microhardness, and density, along with SEM observation and X-ray diffraction analysis were performed. The experimental results showed that the samples with 0.25 and 0.50% Li2CO3 reached a maximum of densification and the highest values of compression strength and microhardness were achieved after sintering at 1300°C. The wetting effect of a Li2O-associated glassy phase was observed even from 900°C.

Abstract: Bovine derived hydroxyapatite was doped with partially stabilized zirconia with 3 mol% yttria. The influence of sintering temperature and the amount of the incorporated zirconia on densification, mechanical properties, crystalline structure and microstructure was investigated. The results indicate that the produced materials exhibit poorer mechanical properties than the relevant composite materials of enamel derived hydroxyapatite. This difference can be attributed to F, since F-content in bone is much higher than in enamel. Hence, in the light of the prospective use of the investigated materials in biomedicine, bovine derived hydroxyapatite doped with zirconia can potentially serve as graft material for load bearing applications if very small amount of F can be incorporated, in order to resemble the composition of enamel derived apatite.