Papers by Keyword: Co-Crystal

Abstract: The paper presents the co-crystal screening study of carbamazepine (CBZ) and ibuprofen (IBU) as a co-crystal former (CCF) using non-stoichiometric (solid addition of CBZ to saturated solution of co-crystal former (CCF) and stoichiometric (1:1 mol of CBZ and CCF) methods. In the non-stoichiometric method, CBZ-IBU co-crystal was prepared in various solvents and left to equilibrate in three conditions; stagnant, manually agitated and shaking in 72 hours whereas in the stoichiometric method, evaporation, solvent drop grinding and dry grinding were used. The crystals produced from the screening process were characterized using differential scanning calorimetry (DSC) and optical microscopy. The co-crystal of CBZ-IBU was found to have successfully formed via the non-stoichiometric method in formic acid. DSC analysis revealed that the remaining crystals produced were either CBZ or IBU as indicated by their respective melting point.

Abstract: Drug discovery from natural products resources have been extensively studied. The most important step in the discovery process is the identification of compounds with interesting biological activity. Single crystal X-ray structure determination is a powerful technique for natural products research and drug discovery in which the detailed three-dimensional structures that emerge can be co-related to the activities of these structures. This article shall present (i) co-crystal structures, (ii) determination of absolute configuration and (iii) the ability to distinguish between whether a natural product compound is a natural product or a natural product artifact. All these three properties are unique to the technique of single crystal X-ray structure determination.