Papers by Keyword: Curcumin

Abstract: A mild, solvent-free method for the encapsulation of curcumin in chitosan–carrageenan nanoparticles was developed by introducing curcumin after polyelectrolyte complex formation but before crosslinking with sodium tripolyphosphate (STPP). This approach was carried out to promote effective encapsulation without interfering with the electrostatic interactions essential for nanoparticle formation. FTIR analysis confirmed the presence of electrostatic and hydrogen bonding interactions among curcumin, chitosan, and carrageenan. Atomic force microscopy (AFM) revealed an increase in nanoparticle size upon curcumin loading, while transmission electron microscopy (TEM) provided morphological evidence supporting encapsulation within the nanoparticle matrix. These results confirm the successful encapsulation of curcumin into chitosan–carrageenan nanoparticles using a strategy that preserves nanoparticle integrity while minimizing curcumin loss. The resulting system presents a promising, eco-friendly platform for curcumin delivery with broad potential in pharmaceutical, nutraceutical, packaging, and food-related applications.

Abstract: This article describes the development and characterization of a curcumin-loaded alginate-xanthan gum hydrogel, designed to provide both antibacterial activity and controlled drug release.The hydrogel formulation consisted of 4% (w/v) alginate, 4% (w/v) xanthan gum, and 500 μg/mL of curcumin. Sterilization was achieved through ethanol immersion, UV irradiation, and autoclaving, with the latter two methods proving to be the most effective in maintaining long-term sterility. Antibacterial efficacy was tested against Staphylococcus aureus, demonstrating a significant inhibition zone around the hydrogel. The curcumin release profile indicated a sustained release over 72 hours, suggesting its suitability for prolonged antibacterial applications.

Abstract: The graphite electrode was changed by applying cyclic voltammetry to electropolymerized curcumin. Then, the polycurcumin-modified graphite electrodes (GECU) were used to determine Cd²⁺ concentration. The results showed that the GECU electrodes had higher electrocatalytic activity toward Cd²⁺ than bare graphite electrodes. Furthermore, the effect of the scan rates showed that the electrochemical process controlling the redox behavior of Cd²⁺ on GECU is a diffusion-controlled electrochemical process. At Cd²⁺ ranging from 0.22 to 11.03 ppm, the relationship between oxidation peak current (Ip) and Cd2⁺ concentration follows the linear regression equation of Ip = 73.024[Cd²⁺] + 722.02 (μA, R² = 0.9936). It means that under experimental conditions, an increase in Cd2+ from 0.22 to 11.03 ppm can increase the Ip value. On the other hand, At Cd²⁺ ranging from 11.03 to 55.07 ppm, the relationship between Ip and Cd²⁺ concentration follows the linear equation of Ip = 24.227[Cd²⁺] + 1212.6 (μA, R² = 0.9920). The LOD and LOQ were determined at low Cd²⁺ concentrations, namely 0.86 ppm, and 2.84 ppm, respectively. Furthermore, the suggested modification has been used successfully and with satisfactory recoveries to determine the presence of Cd²⁺ in laboratory liquid wastewater.

Abstract: Type 2 Diabetes Mellitus (DM) is characterized by elevated blood glucose. Curcumin has glucose-lowering properties. This review intended to determine if Curcumin can lower blood glucose levels in type 2 diabetic patients. This review intended to determine if Curcumin can decrease blood glucose in type 2 DM patients. Curcumin has a mechanism of stimulating incretin and inhibiting digestive enzymes from reducing blood glucose levels in type 2 DM patients. We systematically searched PubMed for peer-reviewed studies examining the mechanism of Curcumin in decreasing blood glucose in type 2 DM patients. The journal criteria included in this review were a study from 2000 to 2022, randomized control trial using intervention Curcumin, an outcome variable using blood glucose, the full text of the article can be obtained, and the DM patient's age is over 18 years. Two independent reviewers retrieved data o clinical outcomes, studies, and patient characteristics using the Cochrane Risk of Bias Assessment Instrument. Quality is evaluated using the Grading of Recommendations Assessment, Development, and Evaluation system. There are 19 studies included in this research, and Three journals meet the requirements. The conclusion is that curcumin can decrease blood glucose in Type 2 DM patients.

Abstract: Abstract The aim of this study was to fabricate curcumin-loaded polymeric mixed micelle which was a new nanocarrier of therpeutic agent for skin uses. Curcumin was extracted from dried turmeric rhizomes using ethanol and recrystallized. The purity of curcumin was 79±3.6 %w/w. Six curcumin-loaded polymeric micelles (PM1-PM6) were prepared by simple dissolution method using poloxamer 407 (5% and 10%) as a main core structure. PEG-40 hydrogenated castor oil (PEG-40HCO) was incorporated at two percentages (2.5% and 5.0%) to study the effect on the nanoparticle characteristics. The average particle sizes of PM1-PM6 were in the range of 33.3±6.6 nm to 171.3±52.8 nm. The entrapment efficiency and the loading capacity of curcumin were in the range of 47.45%-77.35% and 0.048%w/w-0.078%w/w, respectively. When PEG-40HCO was incorporated in to the polymeric micelles, the particle size decreased and the entrapment efficiency increased. Thus, PM4 and PM5 were selected for further study. Moisturizing antioxidant creams containing 0.005%w/w of curcumin loaded in PM4, PM5 and curcumin simply dissolved in propylene glycol (PG) were formulated. The resulted formulations showed good spreadability and good characteristics. After being subjected to accelerated test, all of the formulations remained with characteristic color, pH and showed no phase separation. The stability data showed that the moisturizing antioxidant creams were stable for the whole 3 months after storage at accelerated temperature (45°C/75%RH). The study demonstrated that polymeric mixed micelle spontaneously encapsulated a poorly water-soluble curcumin and increased the solubility up to 250 folds. The developed moisturizing cream containing 0.005%w/w of curcumin resulted a greenish-yellow color preparation. It had tolerable physicochemical properties based on curcumin content, pH and viscosity under the harsh condition. The cream also had satisfactory antioxidant activity, which can be regarded as an effective and acceptable therapeutic or skincare products for topical uses.

Abstract: This work aimed to investigate the effect of cisplatin (CDDP)/curcumin (Cur)-loaded polycaprolactone nanoparticles (PCL-NPs) on an oral epidermal carcinoma cell line. PCL-NPs were fabricated using nanoprecipitation method employing poly(vinyl alcohol) and polysorbate 80 as stabilizers. Two anticancer compounds, CDDP and Cur, were incorporated into the PCL-NPs by entrapment technique. The physical characteristics of the NPs were evaluated. The presence of the drugs on the NPs was ascertained using Attenuated total reflection Fourier-transformed infrared (ATR-FTIR) spectroscopy, and the drug content was quantified by indirect method using ultraviolet spectroscopy and inductive coupled plasma-mass spectroscopy. The cytotoxic effect was demonstrated using MTT assay and the synergistic effect of both drugs was calculated by the combination index method using CompuSyn^® software. The findings revealed that the PCL-NPs were less than 300 nm with narrow size distribution. The appropriate drug concentration for drug loading was 0.12 mg/mL of Cur and 0.02 mg/mL of CDDP, providing approximately 70% and 80% loading efficacy, respectively. The improved anticancer effect was observed in the cells treated with mixture of the drugs and the NPs loaded with dual drugs. Above all, CDDP/Cur-loaded PCL-NPs were successfully prepared. The delivery system exhibited good anticancer effect against oral cancer cells which may be attributed to the synergism effect of CDDP and Cur loaded on the NPs.

Abstract: Curcumin is a phytochemical compound extracted from the rhizomes of the plant Curcuma longa and shows intrinsic anti-cancer properties. Its medical application remains limited due to its extremely low water solubility and bioavailability. Addressing this problem, drug delivery systems based on nano-scale technology have emerged. Among the advanced techniques, the self-nano-emulsifying drug delivery system (SNEDDS) has been considered as an ideal method to enhance the oral absorption and bioavailability of poorly water-soluble drugs. The objectives of present study are to prepare a formulation of nanoemulsion containing curcuminoids of natural origin, assess its micro properties, stabilities and evaluate the in vitro cytotoxic activity against some cancer cells using tetrazolium dye MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazo- lium bromide] (MTT assay). Measurement results showed that the curcumin nanoemulsion was successfully synthesized with typical mean droplet sizes from 9 to 11 nm, and revealed an excellent stability over time. Curcumin in a nanoemulsion was more stable than unencapsulated curcumin. In vitro experiments on cytotoxic activities against Hela, HepG2 and H460 cancer cell lines indicated that the prepared curcumin nanoemulsion effectively inhibited the growth of all three cell lines with IC50 values of 8.6 µM, 14.5 µM and 5.3 µM respectively. Results of this study suggest that curcumin nanoemulsion can be considered as novel and promising chemo-preventive and therapeutic drug in treatment of cancer, and it may supply some useful ideas in developing anticancer drugs for further in vivo studies.

Abstract: Chitosan (CS) is known for excellent biodegradability and low immunogenicity. However, its low water solubility has hampered CS biomedical application. In this study, we aimed to modify CS with polyethylene glycol (PEG) to improve water solubility and explored the possibility to use as a drug delivery vehicle. Degree of substitution of PEG on CS was varied, ranged from 16% to 78%. After dispersing in water, CS-PEG₇₅₀ and CS-PEG₅₀₀₀ could spontaneously form small nanoaggreagtes (NGs) at low concentration, with critical aggregation concentration ranged from 32 μg/mL to 112 μg/mL. Upon encapsulation of curcumin, all NGs were slightly bigger in size. CS-PEG₇₅₀ (1:40) NGs showed the highest entrapment efficiency at 59%, while CS-PEG₅₀₀₀ (1:40) and (1:60) NGs exhibited 36.9% and 36.5% entrapment efficiency, respectively. With few steps of modification, this modified CS copolymers reveal improved water solubility and decent entrapment efficiency. Thus this copolymer is a potential contender as a drug delivery vehicle.

Abstract: Curcumin, a diarylheptanoids compound which isolated primary from Curcuma longa, exhibits a variety of exciting biological activities, including as an antibacterial agent. In the present study, a sulfanilamide-contained curcumin compound was synthesized and characterized to investigate the antibacterial activity against gram-positive bacteria S. aureus, B. subtilis and gram-negative bacteria E. coli. The characterization of the synthesized compound was determined by analysing peak absorbance, functional group, and molecular weight using mass spectroscopy, UV/Vis and FTIR spectrophotometry. Curcumin-sulfanilamide compound exhibited the best antibacterial activity against gram-negative bacteria compared to curcumin and the curcumin-derived compound containing isoxazole with inhibitory zone of 11 mm.

Abstract: In thus study, Turmeric phosphor dye was extracted from Curcuma Longa L. via a simple technique using silica gel. The phosphor was used for light down-conversion of UV light for the manufacture white light emitting diode (WLED). The UV-LED was analyzed over 395nm wavelengths. The characteristics of the white light chromaticity were controlled by tuning the current and phosphor concentration. An optimum color rendering index (CRI) value of 63.4 was obtained. The chromaticity coordinates (CIE) and correlated color temperature (CCT) were measured for various currents and phosphor concentrations. The white phosphor exhibited CIE value of 0.355,0.338 and CCT of 4567 K. The concentration of phosphor and amount of applied current were confirmed to be major factors that control the intensity of white light emitted from the sample, where CIE and CRI of the emitted light steadily increased with the concentration of phosphor and current. Thus, phosphor concentration has a critical effect on conversion efficiency. Key words: Turmeric, phosphor, WLED, curcumin