Papers by Keyword: Erythromycin

Abstract: The presence of residual antibiotics in soil and water ecosystems has harmful effects on the environment, ecological food chain, and human health. It is also a driving factor for bacterial antibiotic resistance. Erythromycin is an antibiotic found in the water bodies in several countries due to improper disposal or inefficient wastewater treatment. Biochar is an adsorbent material prepared by the pyrolysis of discarded waste items including food and garden waste that could provide a cost-effective and efficient method for eliminating antibiotics from wastewater. This study evaluated whether biochar is successful in removing the antibiotic erythromycin from an aqueous environment through adsorption. It also investigated whether various factors such the pH of the aqueous environment or the concentration of erythromycin impacted its adsorption. Lastly, it was compared to commercially available activated charcoal to determine which material adsorbs erythromycin more effectively. The biochar is obtained from the pyrolysis of solid domestic waste including food, paper, and garden waste at 300°C. All experiments were conducted over three hours at neutral pH and the adsorption onto 1.0 g (±1 mg) of biochar was calculated in mg/g. The solutions were continuously stirred at 200 rpm and the temperature was set to 23°C. Samples were analysed using reverse-phase high-performance liquid chromatography (HPLC) at 210 nm using a mixture of methanol-water at alkaline pH (80:20, v/v) as a mobile phase. It was found that the highest concentration of erythromycin, 100 mg/L showed a better adsorption capacity (3.71 mg/g) compared to samples at a concentration of 50 mg/L (1.90 mg/g) and 25 mg/L (0.95 mg/g). In addition, samples obtained from the neutral (pH 7) solution showed slightly greater drug adsorption in comparison to samples obtained from the acidic (pH 5) and alkaline (pH 9) solutions. Lastly, biochar was more effective than activated charcoal in adsorbing erythromycin where a 1.0 g of biochar adsorbed almost twice the amount of the drug. Overall, this study suggested the use of a biochar prepared from discarded materials as a simple cost-effective additional method for removing erythromycin from water which could be further optimised or combined with another method achieve a full elimination.

Abstract: As a kind of ideal porous absorbents with tunable porosity, large surface areas, and hydrophobicity, conjugated microporous polymers (CMPs) have recently received extensive attention in oil/organic solvent-water separation. However, reports on the application of CMPs in adsorption of erythromycin (ERY) from water are very few. In this work, the adsorption of ERY by three kinds of CMPs was firstly studied. It was observed that all the CMPs extracted ERY quickly from water. The adsorption kinetics of ERY on the three CMPs was well expressed by the pseudo-second-order model, and the adsorption process was found to be mainly controlled by film diffusion. Increasing surface area of the CMPs resulted in greater extent of adsorption. This work may provide fundamental guidance for removal of antibiotics by CMPs.

Abstract: Molecular imprinted polymers were synthesized with precipitation polymerization in the present study when Erythromycin was used as template, methacrylic acid as functional monomer, and ethylene glycol dimethacrylate as cross-linker. The best synthesis solution was ultimately determined when the bonding property of the polymer was studied. The selectivity of imprinted polymer on Erythromycin was also studied. The equilibrium binding experiments showed that the binding site of MIPs was heterogeneous with one binding site. Equilibrium dissociation constant was 0.663mg/ml, maximum apparent adsorption was 91.39mg/g.

Abstract: Erythromycin molecularly imprinted polymeric microspheres（EM-MIPMs) which have good shape and well-distributed size were prepared by suspension polymerization in aqueous phase, using EM as a template and methacrylic acid (MAA) as a functional monomer. The size of MIPMs is about 50.17 μm characterized by laser particle size analyzer and polarizing microscope. The interaction between the template and monomer, and selective binding performance were investigated by ultraviolet spectrum analysis, equilibrium binding experiments and Scatchard analysis. The results show tha t hydrogen bonding may contribute to the interaction between EM and MAA, EM-MIPMs demonstrated much higher adsorption capacity compared with the NMIPMs. It has also been found that there are two kinds of binding sites in EM-MIPMs and only one kind in NMIPMs.

Abstract: This work developed a simple and sensitive method for the simultaneous determination of erythromycin (Ery) and haloperidol (Hal) in human urine by capillary electrophoresis with eletrochemiluminescence detection. Under optimized conditions, such as detection potential at 1.25 V, electrokinetic injection at 10 kV for 6 s, separation voltage at 10 kV, 15 mmol/L separation buffer with pH 6.5, 5 mmol/L Ru(bpy)₃²⁺ and 50 mmol/L phosphate buffer with pH 8.0 in the ECL cell, the linear concentration ranges for Ery and Hal were from 0.005 to 0.2 μg/mL and from 0.15 to 6.0 μg/mL, respectively. The detection limits (3σ) for Ery and Hal were 0.002 and 0.06 μg/mL, respectively. When the method was applied to determine Ery and Hal in human urine, the recoveries were 96.5% and 95.1% on an average, respectively.

Abstract: The result of its static adsorption to Fermentation Liquid shows that the new reshaping resin. LX-18G-1 does so well in absorbing the Erythromycin and separating Pigment, its adsorption quantity reach 184ku/mL and the separation for pigmentosus just only 7.8%, comparing with 100ku/ml and 36.5% of the Amberlite XAD-16 resin made by US. Rohm & has Company.

Abstract: Erythromycin molecularly imprinted membranes (EM-MIMs) were prepared by wet phase inversion from imprinted polymers which were prepared by MAA as functional monomer, AN as membrane monomer and EDMA as crosslinker in the presence of erythromycin as template. The influences of the proportion of EM and MAA, cross-linking use level, different initiators and use level as well as extraction time on the imprinted sites and specific separation of EM-MIMs for EM were investigated. The results show that EM-MIMs were provided with more imprinted sites and more excellent separation properties for EM when adding MAA 0.0461mol, EM 0.724mmol, AIBN and (NH4)2S2O8 each 0.12g as initiators, and the mole ratio of EDMA and MAA at 5:1. The extraction of templates was carried out by using absolute ethyl alcohol as eluant and ultrasonic oscillating for 40min.