Papers by Keyword: Ferulic Acid

Abstract: Three curcumin analogs of dimethylaminobenzaldehyde derivatives, i.e., A, B and C were synthesized using a green method using the ultrasound-assisted technique, and the process was compared to the conventional method. The improvements were achieved by decreasing the reaction time from hours to minutes and giving the higher yields of the products. The products were tested as an antidiabetic agent by treated them as an inhibitor for α-amylase activity. The result of α-amylase inhibition showed that curcumin analogs (A, B, C) have high inhibition (77.06; 76.59; 78.34%) with IC₅₀value 23.64; 1.36; and 5.93 μg/mL, respectively. Meanwhile, the α-amylase inhibition of the combination between curcumin analog and ferulic acid showed that the curcumin analog C gave the highest inhibition level of 95.94% with IC₅₀ 13.38 μg/mL. The combination of curcumin analog A and ferulic acid has a strong synergistic effect with a combination index (CI) value of less than 1, i.e., 0.33. These curcumin analogs are quite potent in inhibiting the activity of α-amylase so that it can be a good candidate for antidiabetic drugs.

Abstract: Blending of two polymers can result in a number of new composite materials with enhanced properties and applications in several fields. Biopolymers need to be crosslinked in order to modulate their general properties. Chemical crosslinking is a highly versatile method and is generally carried out using aldehydic compounds. Although these are very good cross-linkers, they are not preferred owning to their physiological toxicity. Therefore, the search for natural crosslinking agents is of great interest. Possible candidates are polyphenols, which are widely distributed as minor but functionally important constituents of plant tissues. Thus, this work investigated the use of polyphenols as natural cross-linking agents to produce new materials, namely methylcellulose-chitosan (MC-CS) biocomposites. Two plant–derived polyphenols, i.e. gallic acid (GA) and ferulic acid (FA), were studied as cross-linking agents. FT-IR, DSC, and SEM techniques were used to investigate the formation of the biocomposites. The results showed that only FA can interact with methylcellulose and chitosan as it formed turbid appearance when the clear solutions of MC and plant–derived polyphenols were mixed. The particle size of MC-FA was in the range of 500-600 nm when using 0.5% of polymer and polyphenol compounds. The CS-FA composite possessed relatively large size (6-8 µm) compared to that of the MC one. SEM analysis showed the differences in surface morphology between the cross-linked MC-CS biocomposites and the polymers. The FT-IR and DSC results also indicated that new compounds were formed.

Abstract: A kind of nonwoven containing ferulic acid is prepared by electrospinning method. It was observed that the diameter of the fiber was about 200 nm by SEM. The antibacterial activities against Escherichia coli and S. aureus were also investigated. The result showed the nonwoven prepared was effective against Escherichia coli, and S. aureus. Furthermore, Fabric UV transmittance test and air permeability were taken. It was found that the nonwoven achieved good UV protection and air permeability.

Abstract: The effect of FA and OFA on performances of the soybean protein-isolate/chitosan composite films was evaluated. The FA and OFA enhanced the tensile strength and thermal stability of the composite films significantly, while they reduced the water vapor permeability to 60.3 % and 72.8 % of the control respectively. Moreover, the OFA was more effective to enhance the tensile strength of the composite films than the FA.

Abstract: The effect of ferulic acid (FA) and oxidized ferulic acid (OFA) on performances of the soybean protein-isolate/chitosan composite films was evaluated. The FA and OFA showed an excellent compatibility and miscibility of in the composite films, and leaded the surface more compact and smooth. The FA and OFA also enhanced the thermal stability of the composite films. The FA and OFA enhanced the performance of the composite films by raising the band energy of the crosslinked molecules.

Abstract: Objective: The determination and ratio of ferulic acid and gastrodin in Xiongma Decoction extract by different extraction process were compared, to provide scientific research basis on creating new drugs, controlling the quality combination of modern Compound Chinese, determining the main effect and compatibility. Methods: Chuanxiong and Tianma were extracted by different extraction method such as the boiling method and ethanol extraction by different concentrations to make ​​Xiongma Decoction. The content of ferulic acid and gastrodin were determination by HPLC to make Xiongma Decoction and their ratio was calculated. Chromatographic conditions of ferulic acid: mobile phase: methanol-0.01 % acetic acid solution (30:70, V/V), the detection wavelength: 310nm; chromatographic conditions of Gastrodin: mobile phase: acetonitrile-0.05 % phosphoric acid (3:97, V/V), detection wavelength: 220nm. Results: The determination of ferulic acid was 0.976mg • ml^-1, gastrodin was 1.586mg • ml^-1, the ratio of ferulic acid and gastrodin was1:1.6 in boiling method; while the determination of ferulic acid was 6.08mg • ml^-1, gastrodin was 3.57mg • ml^-1, the ratio was 1.7:1 in ethanol extraction. Conclusion: There are different determination and ratio, when there is different extraction process in the same prescription. This may bring about changes the main effect in prescription. This suggests that the ratio of the main active ingredient should be included in the quality inspection, when preparation process of the traditional recipe was changed.

Abstract: Object: The antioxidant dose-effect relationship and the mechanism of Xiongma Dripping Pills were study to explore the protective effects of oxidative damage in PC12 cells of different doses of Xiongma Dripping Pills containing serum. Method: Oxidative stress injury model of PC12 cells was established by peroxide hydrogen (H₂O₂), sodium nitroprusside (SNP), content and cell culture supernatant lactate dehydrogenase (LDH) and the liquid content of glutathione peroxidase (GSH-PX) were detected by chemical colorimetric determination. Results: There was a plasma concentration peaked in Xiongma Dripping Pills 8 times (6g•kg^-1) dose group, ferulic acid plasma concentration was 10.59 ± 2.92, the plasma concentration gastrodin 18.13 ± 4.63. H₂O₂ and SNP could cause injury in PC12 cells, and increased LDH leakage, reduce the content of GSH-PX (P<0.01). Gung Ma the Dripping Pills can reduce LDH leakage, increase the content of GSH-PX. Xiongma Dripping Pills 8-fold dose group content is the most significant.Conclusion: There was a significant protective effect on Xiongma Dripping Pills serum containing H₂O₂ and SNP induced oxidative damage of PC12 cells and its mechanism was relevant with clearing the free radicals, enhanceing antioxidant enzyme activity in vivo. There was the most significant effect on Xiongma Dripping Pills 8-fold dose group, and there was positive correlation on plasma concentration and pharmacological effects.

Abstract: Objective: To study the effects of a mixture of ferulic acid and gastrodin on spontaneous activity in mice, we explored the pharmacological effects on the central nervous system. Methods: 50 healthy adult mice were randomly divided into five groups, each 10 mixture times the dose groups, respectively. The negative control group (ig same volume of saline) (ig ferulic acid 0.76mg • kg^-1, gastrodin 1.06mg • kg^-1), a 2-fold dose group (ig ferulic acid 1.52mg • kg^-1, gastrodin 2.12mg • kg^-1), 4-fold dose group (ig ferulic acid 3.04mg • kg^-1, gastrodin 4.24mg • kg^-1), 8-fold dose group (ig ferulic acid 6.08mg • kg^-1, gastrodin 8.48mg • kg^-1). We measured the spontaneous activity in mice before and after the administration of 10min, 20min, 30min, 40min, 50min, 60min, 80min, 100min, 120min, 180min, 240min, 360min. Results: Compared with the negative control group, there was a significant excitatory effect in 1-fold dose of spontaneous activity in mice in 60min, 80min, 100min (P<0.05, P<0.01); while 4-fold and 8-fold dose in 80min (P<0.05, P<0.01). Conclusions: There was an exciting effect of a mixture of ferulic acid and gastrodin in a certain dose range, but not in a dose-dependent manner.

Abstract: High performance capillary zone electrophoresis (HPCE) was used in this text to determine the content of ferulic acid in a ready-made Chinese herbal medicine called AI-FUNUAN-GONG (in pills). Electrophoretic separation conditions: Uncoated fused silica capillary column (75um×49/58cm), injection height 7.5cm, 30mmolL^-1 borax solution, separation voltage 20kV, injection time 10s, detection wavelength 315 nm, experimental temperature 20°C.Linearity was kept in the concentration ranging from 1~62.5 mg·L^-1 of ferulic acid with correlation coefficient of 0.970. The average recovery was 97.541% and RSD value was 6.57%. Sample content of ferulic acid was 0.0715mg/g. This method has the advantages of strong specificity, simpleness, speediness, accurate results and good repeatability in separation and it is useful for determination of ferulic Acid in AI-FU-NUAN-GONG Pills.

Abstract: The effect of modification with transglutaminase (TGase) and 4-hydroxy-3-methoxycinnamic acid (ferulic acid) on properties of tilapia skin gelatin film (TSGF) was researched. The results showed that the peroxide inhibition of modified TSGF increased from 14.7% to 62.0% and 52.1%, when concentrations of TGase and ferulic acid were 0.20 or 1.0 mg·mL^-1. At the same time, the WVP coefficients were lower about 24.2% and 20.6%, respectively. The solubility of TSGF decreased with the increase in concentration of TGase and ferulic acid. As the formation of hydrogen bonds in the structure of the film, the amide A band was shifted towards higher wave numbers after modification.