Papers by Keyword: Protein Folding

Abstract: In order to understand the mechanism of protein folding, carbon nanotubes (CNTs) are introduced. We put forward a method to study protein folding by using CNTs based on the principle that CNTs are mimic ribosomal tunnels, where is the first place for protein folding. The theoretical method could be useful in macromolecule refolding study.

Abstract: Protein folding problem is one of the most important problems in bioinformatics. By combining simulated annealing method with pull moves which is a local move set and conformation update mechanism, we put forward an improved simulated annealing (ISA) algorithm for the two-dimensional hydrophobic- polar (2D HP) protein folding problem. Numerical results show that the ISA algorithm can find the known lowest-energy ground state more rapidly and efficiently than the genetic algorithm (GA) for the several given HP sequences. For the sequence with length 20, we obtain the lower-energy conformation than GA. The performance of the algorithm show ISA is an effective method for protein folding simulation