Papers by Keyword: Pyrazoline

Abstract: Most chemotherapeutic drugs are unable to distinguish between healthy and cancerous cells, resulting in the risk of side effects and drug resistance. There is a continuous effort to find new agents to help bring this disease under control. Compounds with bioactive natural product scaffolds have been of great interest due to their low toxicity and high efficacy. In this study, new naphthalene-based chalcone 1 and pyrazoline 1A compounds were synthesized via a Claisen-Schmidt condensation and cyclo-condensation reaction, respectively. These compounds were characterized using the Fourier Transform Infrared (FT-IR), ¹H, and ¹³C Nuclear Magnetic Resonance (NMR) spectroscopy. The molecular docking activities were performed to study the interactions between these new compounds with breast cancer protein, 3ERT as estrogen receptor-α (ERα). Chalcone 1 and pyrazoline 1A compounds obey Lipinski's rule whereby pyrazoline 1A showed the lowest binding energy of -9.47 kcal/mol, inhibition constant of 113.93 mM and log P of 2.30. Interaction of pyrazoline 1A with 3ERT protein exhibited the hydrogen bonding with GLY521 amino acid, while the hydrophobic interactions were observed with LEU346, LEU384, LEU391, LEU525, LEU387, MET343, ALA350, and MET421 amino acids. Pyrazoline 1A is expected to show promising activities as an anticancer agent.

Abstract: s Heterocyclic compounds like pyrazoline was synthesized along to the reaction of phenyl hydrazine hydrochloride with 3-(benzo [c][1,2,5] oxadiazol-4-yl)-1-phenylprop-2-en-1-one undergoing in reflux condition. This compound going to begood yields.A thoroughly fresh compound wasindicating by IR, ¹H, and ¹³C elemental analysis. Stimulate the calculated HOMO/LUMO, MEP and mulliken population analysis and NLO was compare to the experimental analysis of this data. The optimized theoretical structure parameters betide collate to the satisfied assent with the experimental structure. Keywords: Pyrazoline, Heterocycles, NLO, HOMO/LUMO, Optimized structure, Mulliken charges. Graphical Abstract

Abstract: Simple, sensitive and accurate spectrophotometric methods have been developed for the determination of Sulphamethoxazole (SMZ) drug . This method based on the reaction of Sulphamethoxazole (SMZ) with new organic reagent (BYN) it was prepare by reaction between ethyl acetoacetate with 2,4-Dinitrophenylhydrazine. The azo dye product shows absorption maximum at 435 nm. The linearity ranges of Sulphamethoxazole are (2-14 μg.mL^-1) with molar absorptivity (14412.77 L.mol^-1.cm^-1), Sandell's sensitivity index (0.0175 μg.cm-²) , detection limit and Quantification limit ( 0.057, 0.175 μg / ml) respectively. The results showed there are no interferences of excipients on the determination of the drug. The proposed method has been successfully applied for the determination of sulfanilamide in pure and pharmaceutical formulations.

Abstract: 1N-Acetyl-3-phenyl-5-(3,4,5-trimethoxyl-phenyl)-2-pyrazoline has been synthesized and the crystal structure has been determined by means of single-crystal X-ray diffraction. The pyrazolinyl ring and the phenyl rings at 3 positions of the pyrazoline are almost coplane , with their dihedral angle to be 6.63(2) o. Phenyl ring at 5 positions and pyrazolinyl ring are almost perpendicular, the dihedral angle is 78.03(3) o.

Abstract: We prepared various pyrazoline derivatives which possess dimethylamino-, ethoxy-, isopropyl-phenyl ring at the 5-position of pyrazoline. The nanoparticles of pyrazoline derivative ranging from tens to hundreds of nanometers by the reprecipitation method have been successfully prepared and their optical size-dependent properties have been investigated with UV-vis, fluorescence spectroscopy, DLS (Dynamic Light Scattering) and SEM. The size-dependent optical properties of pyrazoline organic nanoparticles have been observed in the order of dimethylamino- > ethoxy- > isopropyl- in electro-donating characters.