Papers by Keyword: Resistance to Flow

Abstract: Antiplatelet drugs block the formation of blood clots by preventing the clumping of platelets inside arteries, particularly in individuals who have atherosclerosis of their arteries, or are otherwise prone to develop blood clots in their arteries. Atherosclerosis is a slow disease in which arteries become clogged and hardened. Fat, cholesterol, calcium, and other substances form plaque, which builds up in arteries. Hard plaque narrows the passage that blood flows through. That causes arteries to become hard and inflexible. Soft plaque is more likely to break free from the artery wall and cause a blood clot, which can block blood flow to vital organs. In this paper an attempt has been made to investigate the effects of antiplatelet drugs on blood flow and significance of non-Newtonian viscosity through a stenosed artery using Herschel-Bulkely fluid model. Numerical illustration presented at the end of the paper provides the results for the resistance to flow, apparent viscosity and the wall shear stress through their graphical representations.

Abstract: Blood-viscosity reducing drugs like “Pentoxifylline” improve blood flow by making the blood less viscous. The resistance to flow of blood in diabetic patients is higher than in non-diabetic patients. Thus diabetic patients with higher resistance to flow are more prone to high blood pressure. Therefore the resistance to blood flow in case of diabetic patients may be reduced by reducing viscosity of the plasma. Viscosity of plasma can be reducing by giving Pentoxifylline. In this paper an attempt has been made to investigate the blood flow behaviour and significance of non-Newtonian viscosity through a stenosed artery using Bingham Plastic fluid model. Numerical illustrations presented at the end of the paper provide the results for the resistance to flow, apparent viscosity and the wall shear stress through their graphical representations. It has been shown that the resistance to flow, apparent viscosity and wall shear stress increases with the size of the stenosis but these increases are comparatively small due to non-Newtonian behaviour of the blood indicating the usefulness of its rheological character in the functioning of the diseased arterial circulation.

Abstract: In this present study a two-phase model for the influence of aspirin on peripheral layer viscosity for physiological characteristics of blood flow through stenosed blood vessels using Casson’s fluid model has been obtained. Flow of blood with axially non-symmetric but radially symmetric stenosis geometry is considered. The non-linear pressure equations have been solved with help of boundary conditions and the results are displayed graphically for different flow characteristics. It was found that the resistance to flow decreases as stenosis shape parameter increases whereas the resistance to flow increases with increasing values of stenosis length, stenosis size and peripheral layer viscosity. The effects of stenosis severity and wall shear stress are discussed in the present computational analysis. Comparisons between the measured and computed peripheral layer viscosity profiles are favourable to the solutions. As a result it can be concluded that a regular dose of Asprin decreases the blood viscosity by diluting the blood of diabetic patients which ultimately decreases the blood pressure. For the validation of the numerical model, the computation results are compared with the experimental data and results from published literature.