Papers by Keyword: Schiff Base

Abstract: The liver, bones, kidneys, teeth, and central nervous system sustain serious damage as a result of heavy metal ions entering the human food chain. In order to improve public health, new techniques must be developed for the rapid, easy, simple, reliable, low-cost, and reliable identification of toxic metal ions.Naked eye detection of hazardous metal ions with Cu (I) fluorescent properties of Cu(I) Complex of with 2, 2′-bipyridine and trans cinnamic acid were investigated. The structure of the fluorescent Cu (I) complex was characterized by conductivity measurement, elemental analysis, UV-Visible and FT-IR. The Cu (I) complex was soluble in dimethylsulfoxide, distilled water, methanol and insoluble in tetrahydrofuran. In the applications, firstly the color of the Cu(I) complex was compared with/without metal ions, and then the measurements were made in the UV-Vis spectrophotometer to exhibit selective and sensitive to Fe³⁺ ions in DMSO (dimethylsulfoxide) / H₂O (water) (v/v, 1:1). Cu(I) complex exhibited absorbance band at 323 nm in dimethylsulfoxide. The absorbance intensity was decreased by Fe (III) and behaves as a turn-off sensor. The sensor showed high selectively and sensitivity toward Fe (III) over the other cations in dimethlsulfoxide solution. The equilibrium binding constant of Cu (I) complex with Fe (III) was 1.9x10 ⁴ M ^-1 as calculated using stern –volmer equation. The limit of detection was also determined and calculated as 0.219 μM. Based on facts obtained from this study, the author suggests the Copper (I) complex response to Fe (III) rapidly and a large number of consecutive ions showed almost no obvious absorbance change during detection. Copper (I) complex could act as cost effective, selective, specific and sensor for detection of Fe (III) ions over other metal ions.

Abstract: Two potential novels Schiff base iron (Fe) complexes Fe-L² and Fe-L³ (where L²= N, N'-bis (o-hydroxyacetophenone) ethylenediamine and L³= N, N'-bis (o-hydroxybenzaldehyde) phenylenediamine) were synthesized from interaction a hot methanolic solution of each ligand L² or L³ (0.01mole) with the appropriate amount of Fe (NO₃)₃.9H₂O metal salt (0.01mole). This study investigated the cytotoxicity induced by both complexes (0.1 to 100 µg/ml) in MCF-7 and MDA-MB 231 cell lines. After 24 hours of treatment, the cell viabilities of both MCF-7 and MDA-MB-231 cells were linearly proportional to the Fe-L² concentrations. A higher concentration of Fe-L² would cause higher cell killings. On the other hand, most of the Fe-L³ concentrations caused total cell deaths for both cell lines, except for the lowest concentration (0.1 µg/ml). Fe-L² and Fe-L³ also caused lower cell viability of MDA-MB-231 cells compared to MCF-7 cells. Overall, the obtained Fe-L³ is more toxic than Fe-L² in breast cancer cells. It is suggested that the Fe-L³ is an excellent agent against breast cancer cells; meanwhile, the Fe-L² is biocompatible and a good support in medical applications, especially as a radiosensitizer in radiotherapy.

Abstract: The electrochemical synthesis of poly (o-aminobenzyl alcohol) (PABA) coatings containing three different amounts of NiZnFe₄O₄ nanoparticle (NP) with and without 0.25 mM Schiff base (ORG) on stainless steel (SS) was carried out in 0.15 M LiClO₄ containing acetonitrile (ACN) solution. The synthesis curves of PABA-NP and PABA-ORG-NP films exhibited the different current and monomer oxidation potential values indicating the presence of NP and ORG compounds. Besides, the addition of ORG to the NP-containing synthesis solution resulted in an increase in the electropolymerization rate of the PABA film compared to the NP-containing medium alone. Indeed, SEM images of PABA-NP and PABA-ORG-NP also showed that their morphological structures were different. As a result of the evaluation of the impedance analysis, it was seen that PABA-NP and PABA-ORG-NP films provided significant physical barrier behavior to the SS electrode, in 3.5% NaCl solution. PABA-NP₂₅ and PABA-ORG-NP₂₅ coatings exhibited more protection behavior against to the move of corrosive substances to SS. The presence of both NP and ORG in the polymer coating further improved the superior protection property of the PABA film, in a longer time.

Abstract: The investigation of Corrosion inhibition behavior of synthesized amino acid-based Schiff base inhibitor [(E)-5-nitro-N1-((E)-3-phenylallylidene) benzene-1,2-diamine] was carried out. Its adsorption in two types of (5%) soil solutions was studied at room temperature, using potentiodynamic polarization and gravimetric techniques. The inhibition efficiency obtained at the optimum inhibitor concentration (300ppm), were 23% in acidic and 70% in neutral electrolyte. Results illustrated that the inhibitor worked well in less acidic environment in one of the soil solutions which was relatively acidic than the other. Experimental data of potentiodynamic study also indicated that the inhibitor was more inclined to adsorb on the anodic sites of the carbon steel sample, thus the inhibitor can be categorized as the anodic inhibitor due to suppression of more anodic reaction on the carbon steel sample.

Abstract: This study introduced the aldehyde monomer derived from vanillin (4,4-[(1,4-phenylenedimethylene) dioxy] -bis (3-methoxybenzaldehyde), BA), followed by reaction with tris (2-aminoethyl) amine (TA) and diamine (DA) to prepare a series of polyimine films (BADT-X). By adjusting the ratio of TA and DA, BADT-X with different degrees of cross-linking can be obtained, thereby the performance of the film could be tuned. The physical results show that with the increase of TA content, the mechanical performance of BADT-X has been improved from 31.20 to 45.95MPa, furthernore, the degradation temperature (T_d5%) increased from 166.66 to 272.80 °C, and the char yield of all BADT-x was more than 45% at 600 °C. Meanwhile, the quick reshape properties of this polyimine film can be accomplished without any external catalyst in 5 mins at elevated temperature.

Abstract: Artificial metal enzymes that combine proteins with synthesized unnatural metal complexes as cofactors are attracting attention. The preparation of artificial metal enzymes not only clarifies the behavior of metal ions in biology, but also leads to the development of synthetic chemistry fields such as the discovery of new catalytic reactivity and substrate selectivity that are not observed in nature. In addition, a certain Schiff base zinc (II) complex is known to exhibit antioxidant and anticancer activity, too. Therefore, in this study, we investigated a rapid synthesis method of two known amino acid Schiff base zinc (II) complexes using microwave method and the complexation of zinc (II) complex with chicken egg white lysozyme, which is a relatively low molecular weight protein. Furthermore, investigation of weakly non-covalent intermolecular interaction features between the zinc (II) complexes and lysozyme was also carried out using some spectroscopic measurements.

Abstract: In this research, the actions of antibiotic trimethoprim alone and with metals combained. Then assayed through formation of base transition metal compounds as ligands have the chance to achieve an unusual arrangement and stability complexes of coordination. We show advancement in using transtional metal compounds medications for treamentt manyl human illnesses such as carcinomas, lymphomas, control of infections, anti-inflammatory disorders, diabetes, with neurological conditions. This combination with transition metal observed the interaction can be separated by derivative spectroscopic method and measure the characterization of compound by IR and UV spectroscopy.

Abstract: Being one of the hazardous contaminants in the environment, continuous exposure to cadmium ions (Cd (II)) has been shown to severely affect the well being of both humans and animals. Therefore, development of a highly sensitive method to detect trace amounts of such substance in the environment acquires scientific pertinence. In this present work, carbon paste electrode modified with bis (benzylidene) ethelynediamine (BBE-CPE) was used for the determination of Cd (II) using square wave anodic stripping voltammetric (SWASV) technique. A response surface methodological approach employing the Box-Behnken design (BBD) based on four relevant variables; pH, deposition time, percentage ligand and deposition potential was used for optimizing the experimental conditions for detecting such ions. Under optimized conditions (supporting electrolyte: pH 4.5, deposition time: 350 s, ligand graphite composition: 6%, deposition potential: ‒1.1 V), a linear response over a wide range of Cd (II) concentrations (1–500 μg L⁻¹) with low detection limit (0.4 μg L^-1) and quantification limit (1.4 μg L^-1) were observed with deposition time being the most impacting factor. Pertinently, the BBE-CPE developed here exhibited exceptional recovery of Cd (II) concentrations in the sea and tap water samples, comparable with that observed under simulated conditions, suggesting its applicability for a variety of real samples.

Abstract: Design and synthesis of supramolecular hybrids with low dimensionality is currently an attractive research topic. The reaction of Schiff base metal complex with isopolymolybdate leads to the isolation of a new isopolymolybdate based supramolecular hybrid, [Mn(salen)(H₂O)₂]₂[Mo₈O₂₆]Na₂·2H₂O (1) (salen = N,N'-bis(salicylidene)ethylenediamine). The supramolecular hybrid was characterized by single crystal X-ray structure analyses, elemental analyses and X-ray crystallography. Crystal data for 1: triclinic, P-1, a=10.0206(8)Å, b = 11.7416(10)Å, c= 13.1494(13)Å, V = 1382.8(2)ų, Z= 1, R_gt(F) = 0.0353 and wR_ref(F²) = 0.1009. Structural analyses reveal that 1 represents the first example of [Mo₈O₂₆]^4- chains formed POM-Schiff-base hybrid. Hirshfeld surface analysis and fingerprint plots are used for decoding intermolecular interactions in 1. Additionally, magnetic property of 1 indicates that there is an antiferromagnetic coupling between the metal centers in the complex.

Abstract: Schiff base ligands, having nitrogen and oxygen donor sites and their zinc (II) complexes have been prepared by using methanol as a solvent. Purity of the compounds has been tested by TLC and are characterized by FT-IR, multinuclear NMR (¹H and ¹³C). FT-IR spectra suggested the binding of precursors and their chelation with zinc (II) moieties by showing characteristics peaks in particular regions. ¹H-NMR also approves the synthesis of compounds by showing characteristics peaks of azomethine proton (HC=N) and phenolic proton (-OH). On complexation phenolic proton was disappeared while a down field shift was observed in azomethine proton.¹³C-NMR data further supports the formation of compounds by the displaying and shifting of characteristic peaks of azomethine carbon (HC=N).The DNA binding ability of all the synthesized ligands was studied by UV-Visible spectroscopy. A hypochromic affect was observed showing that ligands interacted with DNA by intercalation. The results implied that these synthesized compounds can be employed for the formulation of Anticancer and Antitumor drugs in future with less toxic side effects to normal cells (unlike toxic drugs presently used) .Moreover they were found to have antifungal and antibacterial activity by Disc Diffusion method. Zinc containing complexes have been investigated a lot recently for the treatment of Diabetes Mellitus. Thus, these synthesized compounds are potential drug candidates for research if explored .