Papers by Keyword: Small Intestinal Submucosa

Abstract: Small Intestinal Submucosa (SIS) is a material used from ancient times in foods, and more recently as a biomaterial. To ensure antibacterial properties, the presence of ionic Ag⁺ is benefic and brings a minimum of toxicity to the SIS. In this paper, the electrochemical oxidation of Ag is considered to obtain the ionic Ag⁺. The simultaneous use of Surface Plasmon Resonance (SPR) and Electrochemical techniques opens an insight on Ag oxidation. The study is undertaken in a Simulated Body Fluid (SBF) with ions concentration that closely resembles the concentrations of the human blood plasma for a simulation of the Ag⁺ ions behavior in physiological conditions. The simultaneous SPR and Electrochemical approach highlighted aspects of the ion adsorption into the SIS membrane.

Abstract: In order to application for the tissue engineered intervertebral disc (IVD), we designed the synthetic/natural hybrid scaffolds with poly(lactide-co-glycolide) (PLGA) and small intestine submucosa (SIS). SIS has been widely used as a biomaterial because SIS consists of various collagens and cytokines. SIS, however, possesses disadvantages such as their weak mechanical properties and uncontrolled degradation. Novel composite scaffolds of PLGA/SIS were manufactured by simple immersion method of PLGA scaffolds in SIS solution under vacuum. Then SIS was crosslinked. Also, PLGA scaffolds and SIS sponges were manufactured by solvent casting/salt leaching and freeze-dried methods, respectively. We evaluated pore structure, porosity, water absorption ability and cell viability of three types of scaffolds for the application of IVD.

Abstract: To develop a wound dressing that can be removed from the injured skin without the damage and supporting rapid healing, we made hybrid dressing of small intestinal submucosa (SIS) and hydrogels. Alginate and gelatin used as a dressing material in hydrogels were selected to coat SIS sheets. Characteristics and tendency of wound healing of prepared sheets were investigated. Water uptake ability was greater when the sheets were coated with gelatin than alginate although both showed higher water absorption than the native SIS sheets, but the degradation rate of alginate/gelatin coated SIS was slower than that of native SIS because both polymers may delay contact time of enzyme to the SIS surface in solution. It was observed that less of fibroblasts attached to the natural polymer coated SIS sheets. This property will make easy for the detachment of the sheet from the defected tissue. Wound closure examination showed that prepared sheets enhanced wound healing. It was concluded that prepared alginate/gelatin coated SIS sheets are positively regarded as an appropriate biodegradable wound dressing that is reducing patient’s pain during change of the dressing.