Papers by Keyword: Small Molecule

Abstract: DNA G-quadruplex (G4-DNA) has emerged as a new drug target for anti-tumor. The small compounds can induce the formation of G4-DNA and stabilize its structures, which is of potential significance for the tumor treatment. This paper focuses on our current understanding about the structure of G4-DNA, the binding mode between G4-DNA and small molecular ligands, and natural products targeting G4-DNA.

Abstract: A reusable electrochemical biosensing strategy based on structure-switching hairpin probe for the detection of small molecules is proposed using cocaine as the model analyte. Aptamer probe hybridized with the immobilized signal probe to form DNA duplex. When target small molecule was added, competition between target molecule and the signal probe with the aptamer probe happened, which induced the signal probe from stretched duplex to hairpin structure. By measuring ac current voltammetry, the target molecule can be sensitively detected in a linear dynamic range from 1 nM-1000 nM with a low detection limit of 0.7 nM. In particular, the biosensor can be easily regenerated by melting in hot water, making it reusable.

Abstract: Interfaces are inherent in and essential to organic electronic devices. At every interface, both organic/organic and organic/inorganic, the potential to utilize nanostructuring to control device performance is very high. In this paper, we focus on one example of nanostructuring at the donor/acceptor heterojunction in organic photovoltaics, with the purpose of modifing efficiency by four orders of magnitude. We show that the length of the exciton dissociating interface can be tuned by changing the substrate temperature for small molecule heterojunction photodiodes based on crystalline DIP/C60 mixtures. Due to the tuneable interface morphology, the performance of such devices can be changed from poor performing planar heterojunctions to higher efficiency ordered nanoscale bulk heterojunction structures. In this way, highly crystalline DIP can be thought of as a natural “bulk” heterojunction.