Papers by Keyword: Spray Freeze Drying

Abstract: Micro-nano drug particle aggregations were prepared by shearing emulsification, high pressure homogenization and spray freeze drying, particle formational process and optimization of preparation conditions were analyzed, and micro-morphologies, particle size distributions, aerodynamic properties, release performances, inhalation and deposition properties were characterized. Results show that the optimum condition is drug supersaturation 2 and liquid feeding rate 800 mL/h. Micro morphologies of aggregations are porous spherical foamy structure formed by flaky micro-nano particles. The aggregations obtain both of the advantages of low density and large porous particles and micro-nano superficial particles. Tap density is only 0.062 g mL^-1, mass median aerodynamic diameter is 0.93μm, aerosol availability is 59.8%, fine particle fraction is 15.80%, and more than 99% drugs dissolve within 5 min. All above properties are effective for drug delivery and release of DPI.

Abstract: The processing of nanocrystalline yttria doped zirconia powder via dry forming routes has been investigated via the granulation of the powder using spray freeze drying (SFD). Free-flowing and crushable powders suitable for either die or isosatic pressing have been achieved via the combination of SFD with additions of up to 2 vol% of Freon 11; the latter reducing the strength of the granules whilst not affecting the powder flowability into the die. The approach has allowed relic-free green bodies of up to 55% of theoretical density to be produced using pressures as low as 250 MPa.