Papers by Keyword: Stents

Abstract: Development of drug eluting biodegradable cardiovascular stent materials offers a promising alternative to conventional bare metallic stents due to their excellent biocompatibility and ability to eliminate long-term complications associated with permanent implants. The study presents a novel drug-eluting bilayer coating comprising inner calcium phosphate (CaP), titanium dioxide (TiO₂) and outer DEX-loaded chitosan for magnesium alloy stents. The coating is engineered to enhance corrosion resistance, promote biocompatibility and provide controlled drug release to mitigate restenosis and inflammation. The synergistic properties of CaP-TiO₂ improve the structural stability of the coating, while the chitosan matrix ensures effective drug delivery. In-vitro corrosion measurements and drug release kinetics demonstrate the coating’s potential for dual-functionality as a biodegradable barrier and a therapeutic agent carrier respectively. The innovative approach highlights a significant step towards the development of biodegradable drug-eluting stents tailored for cardiovascular applications.

Abstract: Placement for the treatment of coronary atherosclerotic heart disease (CHD) underwent four revolutionary simple balloon dilatation era, bare-metal stent era, drug stent era and completely biodegradable stent era. Completely biodegradable stent is Current research focus. A computer based search of EMbase (1980-01/2011-12), MEDLINE(1966-01/2011-12), CBM(1978-01/2011-08), PubMed (1999-01/2011-12) and CNKI (1999-01/2011-12) was performed. The keywords weredegradable,stents,biocompatibilityin Chinese and English. Indicators including endothelialization degree of coronary artery and incidence of in-stent restenosis were evaluated. 36 articles were included in the final analysis among 262 articles . We systematically evaluated the biocompatibility of vascular stents constructed different biomaterials in these articles and concluded degradable stents may temporarily support vessel wall, smoothly keep blood flow,inhibit thrombosis in an early stage and newborn endomembrane proliferation in later stage and effectively prevent acute vascular occlusion and reduce incidence of restenosis following stent implantation. Biodegradable stents have good biocompatibility and broad application prospects.

Abstract: Seeking the best layout engine scaffold materials is always the focus of the stent design personnel stent . This object of research in this article is the engine stent of a certain loader. the geometric structure model is created by Solidworks. On this basis, finite element model is created in ANSYS. Structure of stent is optimized topologically by using variable density of topological optimization algorithm in which bracket stiffness is been as the optimization objective and reduce the materials quality is been as the state variables. And stent is modeled secondly by using gotten the most optimal topological model. The stress and deformation of the improved stent of engine increased. But weight of stents is reduced by 8.7%.

Abstract: Atherosclerosis, which is caused by endothelial dysfunction, vascular inflammation, and the build-up of lipids, cholesterol, calcium, and cellular debris within the intima of the vessel wall, is one of the most important complications of health. Vascular stenting is the procedure of implanting a thin tube into the site of a narrow or blocked artery due to atherosclerosis. However, the application of vascular stents using conventional metals is limited because the implantation process will cause significant injury to the vascular wall and endothelium, which functions as a protective biocompatible barrier between the tissue and the circulating blood, resulting in neointima hyperplasia followed by the development of long-term restenosis. The objective of this in vitro study was to investigate the endothelial cell function, especially their adhesion behaviour, on highly controllable features on nanostructured surface. Considering the importance of the endothelium and its properties, highly controllable nanostructured surface features of titanium, a popular vascular stent metal, were created using E-beam evaporation to promote endothelialization and to control the direction of endothelial cells on vascular stents. Endothelial cells are naturally aligned with the blood flow in the body. In this manner, the present in vitro study provides much promise for the use of nanotechnology for improving metallic materials for vascular stent applications.