Papers by Keyword: Super-Micro-Particle Pulverization

Abstract: To prepare out a novel preparation of liuweidihuang which effectively preserves Paeonol, Ursolic acid and Polysaccharides, and the preparation process should be scientific, lower-price and simple. The microscopic characteristics and its physicochemical properties of super-micro-particle of liuweidihuang from above process were also discussed. Methods According to the therapeutic and physicochemical properties of materials in liuweidihuang, the processed technology is as follow: Ripe rehmannia glutinosa,Tuckahoe and Alisma digitalis were boiled for 4.5h., the root bark of the peony tree(Paeonia suffruticosa), dogberry and yam were smashed to nanoparticles. Then select the reasonable method to drying the mixture. The microscopic shape characteristics of the before- and after- broken particles was compared. Paeonol content and dissolution were determined by HPLC. The stability and fluidity of liuweidihuang nanoparticles were examined by precipitation and funnel way. Results The approach of prepared liuweidihuang nano-microcapsules is scientific, lower-price and simple. The average size of processed super-micro-particle of liuweidihuang is 400±46nm. The hardness of the table is 9.7kg/cm2. The thickness of the table is 0.6cm. The friability of the tablet is ＜1%. Each tested item complied with standards of troches of Chinese medicine, and it is beneficial to industrial production for Chinese medicine.. Conclusion The nano-microcapsule is dispersive, desiccative, mobilizable, stable and three times concentrated than traditional pills of Liuweidihuang. It also can be used to produce different forms of drugs in the market.

Abstract: Objective In order to increase the Paeonol dissolution and content, cortex moutan were smashed into nanoparticles, and the dissolution and content were compared by microscopy before and after super-micro-particle pulverization. Methods Super-micro-particle pulverization and general grinding were used to broke Cortex moutan into particles. The microscopic morphous characteristics of the before- and after- ultra-disintegration particles were compared by microscopy. Methods of HPLC was used to determine the content and dissolution of Paeonol with different grinding conditions. Methods of precipitation and funnel way were used to examine the stability and fluidity of cortex moutan nano-particles. Results Cortex moutan powder after super-micro-particle pulverization appears sphere or like-sphere, and its average size is 200nm~300nm. After the superfine grinding Paeonol dissolution increases 76.19% in comparison with without nano pulverization. The nanoparticle rest angle is θ=33°.The precipitation ratio of Cortex moutan powder with general grinding is 0.28 at 24h, and the precipitation ratio of its nano-power has been to 0.98 at 60min. Conclusion Paeonol dissolution, stability and fluidity of Cortex moutan nanoparticles were improved greatly and this nanoparticles is beneficial to industrial production for traditional Chinese medicine.