Papers by Keyword: Thiophene

Abstract: Breast cancer is a major health problem with an increasing number of cases over the years. Few classes of anticancer agents have been developed, but they established toxic effects on normal cells. In this study, a new hybrid anthracene-thiophene chalcone 1 has been synthesized via a Claisen-Schmidt condensation of substituted anthracene aldehyde and a thiophene ketone. The cyclo-condensation reaction of chalcone 1 formed a new anthracene-thiophene pyridine 2. The synthesized compounds were structurally characterized by Fourier Transform Infrared (FT-IR) and Nuclear Magnetic Resonance (NMR) spectroscopy. The molecular docking activities using AutoDock 4.2 software were performed to study the intermolecular interactions between these compounds with breast cancer protein, 3ERT as the estrogen receptor-α. Chalcone 1 showed free binding energy of -9.81 kcal/mol, while pyridine 2 exhibited better free binding energy of -10.45 kcal/mol against 3ERT protein. The interactions in pyridine 2 include one hydrogen bonding with MET343 amino acid and several hydrophobic interactions such as π-σ interaction with LEU384, π-anion interaction with ASP351, π-alkyl interactions with ALA350, LEU346, LEU391, LEU525, and MET388 and also a π-sulfur interaction with MET343. Chalcone 1 has only noncovalent interactions such as π-σ interaction with THR347 and π-alkyl interactions with ALA350, LEU346, LEU349, LEU387, LEU391, LEU525, and MET388. The molecular docking study of these compounds indicated that chalcone 1 and pyridine 2 showed a promising anticancer effect.

Abstract: The aim of this work is to use a residue from shale gas production, known as retorted shale (RS), as an alternative material for processes of sulfur adsorptive desulfurization in liquid fuels such as gasoline or diesel. Therefore, retorted shale samples were chemically modified. Two methods were applied: acid leaching and impregnation. The first method (RS-HCl) was an acid treatment with HCl solution (3M) in proportion of 1.5: 10. The second method (RS-Fe) was a wet impregnation of 20%wt. of Fe followed by calcination at 700°C for 2 h. The adsorbents were characterized by X-ray diffraction (XRD) and scanning electron microscopy (SEM). The adsorption tests were performed using a solution of n-heptane and thiophene to simulate a fuel with an initial concentration of 500 ppm of sulfur. The results showed that both methods significantly altered the structure of the retorted shale, mainly the amount of Fe₂O₃. The adsorption test results indicated that the adsorbents prepared can remove up to 90% of the sulfur present.

Abstract: Surface-enhanced Raman spectroscopy (SERS), having the advantages of high detection sensibility and fast analysis speed, meets the requirements of the detection of sulfur content in simulated gasoline. The optimal preparation conditions of nano-silver substrate which played an important role in enhancing Raman signals was mainly studyed in this paper. Potentiostatic oxidation-reduction method was selected to prepare roughened silver electrode as the nano-substrate. The influences of electrolyte, potential and reduction time were investigated. It shows that bromide ion in electrolytes and nearly balance potential could lead to much better result that relative area intensification factor is equal to 81746.

Abstract: Desulfurization of thiophene from model gasoline was carried out by using large charge number metal (Bi, Sb, Zr and Ru) ion modified NH₄Y-zeolite by batch method. The sulfur uptake increased in the order of HY (0.85 mg/g) < BiY-1 (1.06 mg/g) < SbY-1(1.24 mg/g) < ZrY-1 (1.25 mg/g) < RuY-1 (1.35 mg/g). Sulfur uptake was influenced by Ru contentof RuY, which increased in the order of RuY-0.25 (1.11mg/g) < RuY-1 (1.41mg/g) < RuY-0.5 (1.68 mg/g). Sulfur removal was influenced by aromatics of model gasoline, i.e., sulfur removal of RuY-0.5 (42%) showed higher selectivity for thiophene than CeY-1 (24%) ones when model gasoline with toluene.

Abstract: With different content of thiophene in coking crude benzene, the Orthogonal design experiments of thiophene hydrodesulfurization on a Ti modified Co-Mo-P/γ-Al₂O₃ catalyst were carried out in a micro-reactor under the reaction conditions of 2.3~2.7MPa,275~335°C, 0.5h^-1LHSV and H₂/Oil 600~750. The kinetic parameters and the intrinsic kinetics were acquired by 4-order Runge-Kutta method and the modified Simplex method. The power-law type kinetic model was established and consistent with the experiment data and highly acceptable and reliable.

Abstract: Based on phthalocyanines --SnO₂ as a photo catalyst, this paper uses the degrading difference of thiophene by various catalysts under ultraviolet and visible light irradiation conditions to compare the catalytic effects of the different phthalocyanine compounds --SnO₂ photosensitive catalysts, and summarize the reasons and laws to influence the catalysts’ catalytic performance, and analyze the kinetic process of photocatalytic oxidation reaction, and initially discuss kinetics of photocatalytic oxidation reaction and its products.

Abstract: The synthesis of a new liquid crystal thiophene monomer of (E)-4-(6-(3-(thiophen-3-yl)- acryloyloxy) hexyloxy) biphenyl-4’-ethylbenzoate (LC-M) is presented. The chemical structure of this monomer and intermediate compounds was characterized by FT-IR and ¹H-NMR. The phase behavior was investigated by polarizing optical microscopy and differential scanning calorimetry. LC-M showed nematic threaded and schlieren textures on heating and cooling cycles.

Abstract: Tetraphenylethene-thiophene hybrid exhibits the novel feature of aggregation-induced emission and can detect the explosive in the aggregate state with the K_SV of 1.3 × 10⁵ M¹. This result indicates the new hybrid can work as a sensitive chemosensor.

Abstract: Diphenylamine and thiophene compounds are promising materials for organic light-emitting diodes (OLEDs). We report here, the synthesis and optical property of a novel small molecular weight derivative, N⁴.N⁴,N⁴'.N⁴'-tetrakis (4- (thiophen-2-yl) phenyl)-[1,1'-bipheny-4,4'-diamine (TPPA). The target molecule was synthesized using 4,4'-dibromobiphenyl as the starting material, and the proceeding reactions included bromination, Buchwald and Suzuki coupling reactions. According to the optical characterization of it, the absorption peak and excitation peak is at 351nm and 412 nm, respectively. The luminescence quantum yields (LQY) of TPPA is measured at 61.3%.

Abstract: Sensor response and pattern recognition of polymer-coated single-walled carbon nanotubes (SWNTs) were investigated. Printed circuit board (PCB) with Cu/Au interdigitated electrode was used as sensor platform. SWNTs network was firstly formed on PCB by drop-casting. For polymer-coated SWNTs preparation, poly(methyl methacrylate) (PMMA) and thiophene were employed as polymers to coat on SWNTs by spin coating; PMMA/SWNTs and thiophene/SWNTs. Raman spectra showed no obvious structure changes of SWNTs after polymer coating. Next, gas sensing test was conducted. Pristine SWNTs, PMMA/SWNTs and thiophene/SWNTs were exposed to vapors of ethanol and dichloromethane at room temperature. From normalized sensor response results, it was found that pristine SWNTs and PMMA/SWNTs showed the highest response to ethanol and dichloromethane vapors, respectively. In order to discriminate vapors between ethanol and dichloromethane, pattern recognition technique was utilized. Principal component analysis (PCA) results showed that pattern recognition of ethanol and dichloromethane vapors can be discriminated by using pristine SWNTs and polymer-coated SWNTs sensors.