Papers by Keyword: Tissue Scaffold

Abstract: A porous tissue scaffold depends on its ability to provide functional balance between mechanical strength, pore properties and interconnectivity of pores. High porosity levels, typically greater than 90% and pore sizes above 100µm are required for tissue growth and fixation. Alumina is a stable and very strong bioceramic which, when doped with calcium and phosphate ions, can potentially combine bioactivity with high porosity and high strength. Highly porous alumina foams were synthesized through heat induced chemical breakdown of precursor salt solutions. Pore sizes achieved for foamed alumina with moderate mole fractions are generally larger than 100µm. Foamed alumina with mole fractions on the extreme high and low ends shows lower average pore sizes. Compressive strength of synthesized foams falls in the range of 100kPa to 230kPa, significantly higher than porous biodegradable polymer tissue scaffolds. The significance of this work is that scaffolds can be produced with the unique combination of high porosity, high strength and biocompatibility.

Abstract: The aim of this study was to fabricate a micro-tube scaffold using a biomimetic method (immersion in Simulated Body Fluid, SBF) to coat apatite on cotton fibres. The cotton fibres were first pre-treated using a phosphorylation technique and then apatite crystals were deposited on the fibres by immersing in SBF. Micro-tubes were then formed by burning out the cotton fibres at various temperatures between 950-1250°C. The scaffolds were fabricated by compaction of the micro-tubes in a mould. The compacted micro-tubes were then sintered at various temperatures between 900-1200°C. The biocompatibility and the effects of the surface morphology of scaffolds on cell coverage and proliferation were determined using osteoblast cell culture. The results showed that these scaddolds were biocompatible and able to support cell growth. Future studies include animal studies for biomimetic tissue scaffold as a bone filler substitute material.