Papers by Keyword: d-Metal Complexes

Abstract: Chlorhexidine, 1,1'-hexamethylene-bis-[5-(p-chlorophenyl)-biguanide] is a clinically used antiseptic agent with a broad activity spectrum, effective against either Gram positive bacteria such as Mutans streptococcus or Gram negative bacteria such as Pseudomonas aeruginosa. It has eliminating effects on some mycobacteria. In order to prevent the loss of the biological activity caused by poor solubility of chlorhexidine and to limit the side effects of chlorhexidine when used as antiseptic, we synthesised Zn(II)- and Cu(II)- complexes of chlorhexidine, L1, as well as with chlorhexidine diacetate, L2, in 1:1 and 1:2 M:L molar ratios. Based on the elemental analysis data, IR and UV-Vis spectroscopy, and ESI-MS spectrometry we proposed the appropriate molecular formulae of the complexes.

Abstract: New complexes of Pt(II) with condensation derivatives of ethyl hydrazinoacetate and either 2-acetylpyridine or 2-quinolinecarboxaldehyde, and of Pd(II) with the condensation derivative of ethyl hydrazinoacetate and 2-quinolinecarboxaldehyde were synthesized and characterized by elemental analysis, IR, 1H- and 13C-NMR spectroscopy, and molar conductivity measurements. The complexes have a square planar geometry, ligands binding as bidentates in the neutral form, and the remaining two coordination sites being occupied by chloride ions. Biological activity of new complexes, and of previously synthesized Pd(II), Cd(II), Co(III) and Zn(II) complexes with this ligand type was evaluated by the brine shrimp test. All the complexes showed a moderate activity.