The Ti50Fe22Ni22Sn6 amorphous powder was prepared by mechanical alloying with a high-energy planetary ball mill. Crystallization kinetics of the milled amorphous powders was investigated by DSC. Thermal analysis showed that when the heating rate increasing from 10K/min to 40K/min, the super-cooled liquid region of milled amorphous alloy increased from 93K to 110K. On the basis of the obtained DSC curves, the characteristic temperatures of the amorphous powders could be measured. The equations of Kissinger and Ozawa were used to calculate the crystallization activation energies of the milled amorphous alloy for comparing. The activation energy for the glass transition Eg had the maximum values of 650KJ/mol and 629KJ/mol calculated from Kissinger and Ozawa, respectively. In addition, the second crystallization process had a higher activation energy value comparing with the others crystallization events.