Lysicamine in a Lotus Leaves Extract May Be Responsible for Antibacterial and Anti-Inflammation Activity

Abstract:

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In the course of a search for chemotherapeutic agents inhibiting suspected peridontitis bacteria, extracted and purified substances from lotus leaf were identified by antimicrobial and Anti-inflammation activity tests with use of the broth micro-dilution methods on 96-microwell plate and ELISA assay. The antimicrobial activity of extracts was tested against four microorganisms, namely: Streptococcus mutans , Porphyromonas gingivalis, Actinobacillus actinomycetemcomitans and Candida albicans. The Anti-inflammation activity of extracts was tested for inhibition of inflammatory cytokines IL-8 and IL-6 in macrophage BF24. And one pure component was subjected to spectroscopic analysis using UV, IR, EMI-MS, EIMS, 1H-NMR, 13C-NMR, 1H-COSY and HMQC. Our data showed that the minimum inhibitory concentrations of the pour component was less than 5mg/ml for all four microorganisms and the minimum concentration with anti-inflammation was 0.2mg/ml for both IL-8 and IL-6. The component was determined to be Lysicamine. Thus, we conclude that Lysicamine extracted from lotus leaves may be a potential antibacterial and Anti-inflammation agent for oral infection .

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Periodical:

Edited by:

Barry Tan

Pages:

189-193

DOI:

10.4028/www.scientific.net/AMM.108.189

Citation:

P. Wang et al., "Lysicamine in a Lotus Leaves Extract May Be Responsible for Antibacterial and Anti-Inflammation Activity", Applied Mechanics and Materials, Vol. 108, pp. 189-193, 2012

Online since:

October 2011

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$35.00

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