In many process equipments and mechanical system where a flow needs to be distributed among several outlets, the design is generally based on the assumption that the fluid is uniformly divided among them but practically in never happens. A non-uniform flow distribution imposes a serious design limitation in terms of rise in pressure drops and decrease in thermal performance of the system. Reynolds number being a characterizing parameter of pipe flow is expected to play a significant role in flow maldistribution pattern also. This paper present an experimental study performed on multi channel U-and Z-turn flow configurations where the flow is varied in the practical range of 20000 < Re < 35000. Result shows the presence of maldistribution. It is found that the Re plays an important role in characterizing the flow in terms of channel velocity, axial velocity in header and flow distribution pattern in a specific channel. Maldistribution effect is found to be dominant in the central region in U-turn flow and peripheral region in Z-turn configurations.