Facile Synthesis of N-{2-[4-(2-Pyrimidinyl)-1-Piperazinyl]ethyl} Adamantane-1-Carboxamide

Abstract:

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A facile method for the synthesis of N-{2-[4-(2-pyrimidinyl)-1-piperazinyl]ethyl} adamantane-1-carboxamide(Adatanserin) was developed by using 2-chloropyrimidine and adamantanecarbonyl chloride as the starting material via amidation and N-alkylation, using convergent route to reduce workups and steps in a good yield. The structures of compounds were confirmed by IR spectral, 1HNMR and elemental analyses.

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Periodical:

Edited by:

Huixuan Zhang, Ye Han, Fuxiao Chen and Jiuba Wen

Pages:

1319-1322

DOI:

10.4028/www.scientific.net/AMM.117-119.1319

Citation:

Q. Su et al., "Facile Synthesis of N-{2-[4-(2-Pyrimidinyl)-1-Piperazinyl]ethyl} Adamantane-1-Carboxamide", Applied Mechanics and Materials, Vols. 117-119, pp. 1319-1322, 2012

Online since:

October 2011

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$35.00

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