In this paper, we propose a variant of the QAP-based facility layout problem: the fixed-point facility layout problem (FFLP). .Based on Ant Colony algorithm , we design the modified ant algorithm for solving the general facility layout problem (GFLP). In addition, we also design the ant algorithm for FFLP by increasing the operator of data preprocessing. Analyze the impact of the different parameters values on the results by a lot of data testing. Experimental results show that the algorithm has strong capability of global search and rapid speed of convergence.