This paper presents the techno-economic performance of 600 MW coal-fired power plant with and without MEA-based CO2 capture process, based on the operating data of an existing power plant. The simulation and analysis are based on ASPEN PLUS, with fully consideration of features of existing coal-fired power plants and the integration of CO2 capture process with steam cycle. The results show that, when adopting CO2 capture process, the plant efficiency will decrease significantly. And the cost for electricity will increase dramatically. Through further system integrated optimization, the efficiency fall from 40.28% to 29.61%, which is still tremendous but obviously better performance than before.