Synthesis and Performance of Molecular Imprinted Polymers as Drug Release Controller

Abstract:

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Molecular imprinted polymers were synthesized using α-methylacrylacid as monomer, acetylsalicylic acid as template. Polyethylene glycol dimethylacrylate was taken as cross-linker. UV-Vis spectrophotometer was used to detect the drug-loading and releasing performances of these polymers. The studies showed that the imprinted polymers could load more drugs than non-imprinted polymer, and exhibited a slower drug-releasing rate than the latter at pH 7.4. The content of cross-linker had influences on drug-loading amounts. The imprinted polymer released few drugs at the buffer solution of pH 1.2.

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Periodical:

Edited by:

Han Zhao

Pages:

446-449

DOI:

10.4028/www.scientific.net/AMM.130-134.446

Citation:

H. J. Chu et al., "Synthesis and Performance of Molecular Imprinted Polymers as Drug Release Controller", Applied Mechanics and Materials, Vols. 130-134, pp. 446-449, 2012

Online since:

October 2011

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Price:

$35.00

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