Synthesis and Performance of Molecular Imprinted Polymers as Drug Release Controller
Molecular imprinted polymers were synthesized using α-methylacrylacid as monomer, acetylsalicylic acid as template. Polyethylene glycol dimethylacrylate was taken as cross-linker. UV-Vis spectrophotometer was used to detect the drug-loading and releasing performances of these polymers. The studies showed that the imprinted polymers could load more drugs than non-imprinted polymer, and exhibited a slower drug-releasing rate than the latter at pH 7.4. The content of cross-linker had influences on drug-loading amounts. The imprinted polymer released few drugs at the buffer solution of pH 1.2.
H. J. Chu et al., "Synthesis and Performance of Molecular Imprinted Polymers as Drug Release Controller", Applied Mechanics and Materials, Vols. 130-134, pp. 446-449, 2012